Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.

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Title: Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.
Authors: Han F; Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (F.H., Y.-C.Z.)., Clancy U; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Arteaga-Reyes C; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Thrippleton MJ; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Valdés Hernández MDC; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Jaime Garcia D; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Stringer MS; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Backhouse E; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Chappell FM; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Cheng Y; Department of Neurology, West China Hospital, Sichuan University, Chengdu (Y.C.)., Liu DX; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco (D.X.L.)., Zhang J; Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China (J.F.)., Jochems ACC; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Sakka E; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Jardine C; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., Barclay G; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., McIntyre D; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., Hamilton I; Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, UK (C.J., G.B., D.M., I.H.)., Brown R; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Zhu YC; Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (F.H., Y.-C.Z.)., Doubal FN; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.)., Wardlaw JM; Centre for Clinical Brain Sciences, Department of Neuroimaging Sciences, University of Edinburgh, UK (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School (U.C., C.A.-R., M.J.T., M.D.C.V.H., D.J.G., M.S.S., E.B., F.M.C., A.C.C.J., E.S., R.B., F.N.D., J.M.W.).
Source: Circulation [Circulation] 2026 Jun 09; Vol. 153 (23), pp. 1813-1826. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.126.079493