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Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia.

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Title: Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia.
Authors: Liu P; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zhang S; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Chen BY; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Chang B; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Jiang Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China., Li X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Chen X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Li ZJ; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Yang R; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Wang X; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China., Xu CH; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Liu X; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Liu N; Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China., Jia Y; 2nd ward of Oncology and Hematology Department, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China., Yu PC; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Wang Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Zong LJ; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Hu CL; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Hou H; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Cao D; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Li X; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Deng CH; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Ren YY; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Zhao MY; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Ma X; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Cui R; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Teng D; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Chen M; Department of Hematology, First Affiliated Hospital of China Medical University, Shenyang 110001, China., Wang R; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China., Jin J; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China., Jiang SY; Department of Medical Oncology, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China., Yan X; Department of Hematology, First Affiliated Hospital of China Medical University, Shenyang 110001, China., Xue K; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zhang Q; Department of Medical Oncology, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China., Li J; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Dai E; 2nd ward of Oncology and Hematology Department, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China., Shen S; Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, China., Wang Z; MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, University of Science and Technology of China, Hefei 230027, China., Ye X; Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China., Zhang J; Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China., Liu Y; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China., Cui W; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Lu M; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zhao WL; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Chang CK; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China., He PC; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China., Chen Z; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Chen SJ; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zheng M; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Sun XJ; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Wang L; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Source: Science translational medicine [Sci Transl Med] 2026 May 06; Vol. 18 (848), pp. eadv8951. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+BY%22">Chen BY</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Chang+B%22">Chang B</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Li+ZJ%22">Li ZJ</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Xu+CH%22">Xu CH</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+N%22">Liu N</searchLink>; Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Jia+Y%22">Jia Y</searchLink>; 2nd ward of Oncology and Hematology Department, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China.<br /><searchLink fieldCode="AU" term="%22Yu+PC%22">Yu PC</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Zong+LJ%22">Zong LJ</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Hu+CL%22">Hu CL</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Hou+H%22">Hou H</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Cao+D%22">Cao D</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Deng+CH%22">Deng CH</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Ren+YY%22">Ren YY</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Zhao+MY%22">Zhao MY</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Cui+R%22">Cui R</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Teng+D%22">Teng D</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Department of Hematology, First Affiliated Hospital of China Medical University, Shenyang 110001, China.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.<br /><searchLink fieldCode="AU" term="%22Jin+J%22">Jin J</searchLink>; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.<br /><searchLink fieldCode="AU" term="%22Jiang+SY%22">Jiang SY</searchLink>; Department of Medical Oncology, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; Department of Hematology, First Affiliated Hospital of China Medical University, Shenyang 110001, China.<br /><searchLink fieldCode="AU" term="%22Xue+K%22">Xue K</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Medical Oncology, Fudan University, Shanghai 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Dai+E%22">Dai E</searchLink>; 2nd ward of Oncology and Hematology Department, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, University of Science and Technology of China, Hefei 230027, China.<br /><searchLink fieldCode="AU" term="%22Ye+X%22">Ye X</searchLink>; Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; 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Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Chang+CK%22">Chang CK</searchLink>; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.<br /><searchLink fieldCode="AU" term="%22He+PC%22">He PC</searchLink>; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Chen+SJ%22">Chen SJ</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Zheng+M%22">Zheng M</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Sun+XJ%22">Sun XJ</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
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          Name:
            NameFull: Wang L
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 06
              M: 05
              Text: 2026 May 06
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 848
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1