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Intranasal lipid nanocapsule administration of the new lipophenol quercetin-3-O-DHA-7-O-iPr reduces carbonyl stress and improves behavior in a mouse model of Alzheimer's disease.

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Title: Intranasal lipid nanocapsule administration of the new lipophenol quercetin-3-O-DHA-7-O-iPr reduces carbonyl stress and improves behavior in a mouse model of Alzheimer's disease.
Authors: Otaegui L; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France., Lehoux J; Pôle Chimie Balard Recherche, IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, 34293, France., Begu S; ICGM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Moujellil-Legagneur T; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France.; IGF, University of Montpellier, CNRS, Inserm, Montpellier, France., Zussy C; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France.; IGF, University of Montpellier, CNRS, Inserm, Montpellier, France., Vitalis M; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France., Mathias M; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France.; IGF, University of Montpellier, CNRS, Inserm, Montpellier, France., Beau A; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France., Durand T; Pôle Chimie Balard Recherche, IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, 34293, France., Givalois L; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France.; IGF, University of Montpellier, CNRS, Inserm, Montpellier, France.; Faculty of Medicine, Department of Psychiatry and Neurosciences, Laval University, CR-CHUQ Québec city (QC), Quebec City, Canada., Bernoud-Hubac N; University of Lyon, INSA Lyon, CNRS, LAMCOS, Villeurbanne, UMR5259, 69621, France., Crauste C; Pôle Chimie Balard Recherche, IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, 34293, France., Desrumaux C; MMDN, University of Montpellier, EPHE, INSERM, Montpellier, France. catherine.desrumaux-piazza@umontpellier.fr.; LipSTIC LabEx (ANR-11-LABX0021), Dijon, France. catherine.desrumaux-piazza@umontpellier.fr.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 May 06. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2190-3948
DOI:10.1007/s13346-026-02142-5