mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.
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| Title: | mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway. |
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| Authors: | Cai F; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Huang F; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Goncalves C; Lady Davis Institute, McGill University, Montreal, QC, Canada., Srikannan H; Lady Davis Institute, McGill University, Montreal, QC, Canada., Gagnon N; Lady Davis Institute, McGill University, Montreal, QC, Canada., Guettler EM; Lady Davis Institute, McGill University, Montreal, QC, Canada., Mukeba-Harchies L; Cancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium., Maxwell J; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Su J; Lady Davis Institute, McGill University, Montreal, QC, Canada., Bijian K; Lady Davis Institute, McGill University, Montreal, QC, Canada., Journe F; Cancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium., Rose AAN; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Orthwein A; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA., Del Rincón SV; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.; Lady Davis Institute, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.; Department of Oncology, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca., Miller WH Jr; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.; Lady Davis Institute, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.; Department of Oncology, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca. |
| Source: | Cell death & disease [Cell Death Dis] 2026 May 06; Vol. 17 (1). Date of Electronic Publication: 2026 May 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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