Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension: an open-label, randomized controlled trial.
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| Title: | Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension: an open-label, randomized controlled trial. |
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| Authors: | Jorda A; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Gelbenegger G; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Shapiro NI; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Douglas IS; Department of Medicine, New York Medical College, Westchester Medical Center, Valhalla, NY, United States., Whitman C; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Chen Z; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Hippensteel JA; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Kamphuis LA; VA Center for Clinical Management Research, Ann Arbor, VA, Ann Arbor, MI, United States., Flick RJ; Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States., Harhay MO; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Caldwell E; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Washington, Seattle, WA, United States., Zeitlinger M; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Jilma B; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Iwashyna TJ; Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States.; Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Hough CL; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Science University School of Medicine, Portland, OR, United States.; The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Network, Boston, MA, United States., Auriemma CL; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. |
| Source: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Jul 01; Vol. 212 (7), pp. 1510-1521. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1535-4970 |
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| DOI: | 10.1093/ajrccm/aamag154 |
