Enhancing validation of case-control omics signatures through "minimalist" single-subject analysis (N-of-1 trials): proof of concept in sepsis.

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Title: Enhancing validation of case-control omics signatures through "minimalist" single-subject analysis (N-of-1 trials): proof of concept in sepsis.
Authors: Wilson LS; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States., Pouladi N; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States., Nelson RF; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States., Middleton EA; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, United States.; Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, United States.; Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT 84112, United States., Tolley ND; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, United States., Shabanian M; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States., Kenost C; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States., Campbell RA; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, United States.; Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, United States.; Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT 84112, United States.; Department of Pathology, University of Utah, Salt Lake City, UT 84112, United States.; Department of Emergency Medicine, Washington University, Saint Louis, MO 63110, United States., Rondina MT; Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, United States.; Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT 84112, United States.; Department of Pathology, University of Utah, Salt Lake City, UT 84112, United States.; Geriatric Research, Education, and Clinical Center (GRECC), G.E. Wahlen VAMC, Salt Lake City, UT 84148, United States., Lussier YA; Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, United States.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, United States.; Center for Genomic Medicine, University of Utah, Salt Lake City, UT 84112, United States.
Source: Journal of the American Medical Informatics Association : JAMIA [J Am Med Inform Assoc] 2026 Jul 01; Vol. 33 (7), pp. 1293-1303.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9430800 Publication Model: Print Cited Medium: Internet ISSN: 1527-974X (Electronic) Linking ISSN: 10675027 NLM ISO Abbreviation: J Am Med Inform Assoc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1527-974X
DOI:10.1093/jamia/ocag061