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Esterase-responsive albumin-binding PROTAC-mediated BRD4 degradation for cancer immunotherapy.

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Title: Esterase-responsive albumin-binding PROTAC-mediated BRD4 degradation for cancer immunotherapy.
Authors: Lee H; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Korea., Jeong S; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.; Medicinal Materials Research Center, Biomedical Research Division, Medicinal Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea., Park J; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Son HJ; College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea., Kweon S; College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea., Lee SS; Department of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, IL, USA., Shim N; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Oh Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Kang H; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Korea., Lee C; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Korea., Lee J; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Korea., Kim J; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Cho H; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.; Noxpharm Co., LTD., Seoul 03759, Republic of Korea., Kim K; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Korea.
Source: Theranostics [Theranostics] 2026 Apr 23; Vol. 16 (11), pp. 6240-6265. Date of Electronic Publication: 2026 Apr 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1838-7640
DOI:10.7150/thno.130510