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Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial.

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Title: Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial.
Authors: Renú A; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomédiques Agust Pi I Sunyer, Barcelona, Spain., Fernández-Couto MD; Department of Neurology, Complexo Hospitalario Universitario A Coruña, Coruña, Spain., de la Riva P; Department of Neurology, Donostia Ospitalea, San Sebastián, Spain., Delgado-Mederos R; Department of Neurology, Son Espases University Hospital, Palma Mallorca, Spain., Herrera M; Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Spain., Morales A; Department of Neurology, Virgen de la Arrixaca University Hospital, El Palmar, Spain., Terceño M; Department of Neurology, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain., López-Hernández N; Department of Neurology, Dr Balmis General University Hospital, Alicante, Spain., Martínez-Galdámez M; Interventional Neuroradiology Unit, Department of Radiology, University Hospital Valladolid, Valladolid, Spain., Dorado L; Department of Neurology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain., Vega P; Interventional Neuroradiology Unit, Department of Radiology, Hospital Universitario Central de Asturias, Oviedo, Spain., Morales-Caba L; Neurology Department, La Fe University and Polytechnic Hospital, Valencia, Spain., González E; Interventional Neuroradiology Unit, Department of Radiology, Cruces University Hospital, Barakaldo, Spain., Alonso M; Department of Neurology, Donostia Ospitalea, San Sebastián, Spain., Barredo Benítez P; Department of Neurology, Dr Balmis General University Hospital, Alicante, Spain., Bermejo R; Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Spain., Cabero-Arnold A; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Cabrera-Maqueda JM; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Vargas M; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Calleja Bonilla Á; Department of Neurology, Son Espases University Hospital, Palma Mallorca, Spain., Calleja S; Neurology Department, Hospital Universitario Central de Asturias, Oviedo, Spain., Díaz-Pérez J; Department of Neurology, Virgen de la Arrixaca University Hospital, El Palmar, Spain., Rudilosso S; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomédiques Agust Pi I Sunyer, Barcelona, Spain., Doncel-Moriano A; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Feal MJ; Department of Neurology, Complexo Hospitalario Universitario A Coruña, Coruña, Spain., Gallego JI; Department of Neurology, Dr Balmis General University Hospital, Alicante, Spain., Hurtado P; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Laredo C; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Llull L; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Bartolomé I; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Martínez-Calvo A; Department of Neurology, Complexo Hospitalario Universitario A Coruña, Coruña, Spain., Ortega-Sánchez Á; Department of Neurology, Son Espases University Hospital, Palma Mallorca, Spain., Rodríguez-Vázquez A; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Rodríguez-Caamaño I; Department of Neurology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain., Singla A; Avania Europe-Barcelona, Barcelona, Spain., Silva Y; Department of Neurology, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain., Tarruella Hernández D; Neurology Department, La Fe University and Polytechnic Hospital, Valencia, Spain., Oleaga L; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.; Barcelona Clinical Coordinating Center-Corelab Barcelona, Barcelona, Spain., San Román Manzanera L; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain., Serena J; Department of Neurology, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain., Freijo MM; Biobizkaia Health Research Institute, Bilbao, Spain.; Stroke Unit, Department of Neurology, Osakidetza, Cruces University Hospital, Bilbao, Spain., Pérez de la Ossa N; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Castellanos M; Department of Neurology, Complexo Hospitalario Universitario A Coruña, Coruña, Spain., Arenillas-Lara JF; Department of Neurology, Stroke Program, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.; Neurovascular Research Laboratory, Instituto de Biología y Genética Molecular, Valladolid, Spain.; Consejo Superior de Investigaciones Científicas, Universidad de Valladolid, Valladolid, Spain., Torres F; Medical Statistics Core Facility, Clinical Pharmacology Service, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.; Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain., Leira EC; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City.; Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City.; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City., Amaro S; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomédiques Agust Pi I Sunyer, Barcelona, Spain., Urra X; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomédiques Agust Pi I Sunyer, Barcelona, Spain., Chamorro Á; Comprehensive Stroke Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomédiques Agust Pi I Sunyer, Barcelona, Spain.
Corporate Authors: CHOICE-2 Investigators
Source: JAMA [JAMA] 2026 Jun 02; Vol. 335 (21), pp. 1859-1869.
Publication Type: Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1538-3598
DOI:10.1001/jama.2026.5164