Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design.
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| Title: | Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design. |
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| Authors: | Skelly AN; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gavor E; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Connell AJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kreider EF; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Marchitto L; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hogarty MP; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Newby ML; School of Biological Sciences, University of Southampton, Southampton, UK., Allen JD; School of Biological Sciences, University of Southampton, Southampton, UK., Liu W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Ayyanathan K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Campion MS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Winters K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gordon CG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Osbaldeston RA; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Akeley MJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lewis E; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Singh A; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cruickshank K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhao C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Van Itallie E; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Carey JW; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Albertus A; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., DeLaitsch AT; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Lituchy MG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Walsh AA; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Morris DJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mishra N; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Avillion G; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Koranda NS; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Plante SJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Martella CL; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lora J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang EJD; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Lewis MG; Bioqual, Inc., Rockville, MD, USA., Martin MA; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Nussenzweig MC; Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, Rockefeller University, New York, NY, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Irvine DJ; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Wiehe KJ; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Haynes BF; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Wagh K; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Korber B; Los Alamos National Laboratory, Los Alamos, NM, USA.; New Mexico Consortium, Los Alamos, NM, USA., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton, UK., Weissman D; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
| Source: | Science (New York, N.Y.) [Science] 2026 Jun 18; Vol. 392 (6804), pp. eaec6396. Date of Electronic Publication: 2026 Jun 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aec6396 |
