Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial.

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Title: Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial.
Authors: Cooper S; The Royal Marsden NHS Foundation Trust, London, UK sian.cooper@rmh.nhs.uk.; The Institute of Cancer Research, London, UK., Alexander S; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK., Breitkreutz D; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Casey F; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK., Christodouleas J; Elekta AB, Stockholm, Sweden., Dassen MG; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Dell'acqua V; Elekta AB, Stockholm, Sweden., Dunlop A; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK., Herbert T; The Royal Marsden NHS Foundation Trust, London, UK., Kolias P; Department of Mathematics, Aristotle University of Thessaloniki, Thessaloniki, Greece., Mitchell A; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK., Pos FJ; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Westley R; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK., Tree AC; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK., Van Der Heide UA; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Vesprini D; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Source: BMJ open [BMJ Open] 2026 May 07; Vol. 16 (5), pp. e111791. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2044-6055
DOI:10.1136/bmjopen-2025-111791