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Oleuropein attenuates steroid-induced osteonecrosis of the femoral head by inhibiting osteoblast apoptosis via activation of the PI3K-AKT-Bcl2 pathway.

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Title: Oleuropein attenuates steroid-induced osteonecrosis of the femoral head by inhibiting osteoblast apoptosis via activation of the PI3K-AKT-Bcl2 pathway.
Authors: Lin J; Department of Orthopedic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian Province, China.; Department of Orthopedic Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian Province, China., Zhang R; Department of Orthopedic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian Province, China.; Department of Orthopedic Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian Province, China., Lin X; Department of Orthopedic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian Province, China.; Department of Orthopedic Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian Province, China., Luo X; Department of Orthopedic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian Province, China.; Department of Orthopedic Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian Province, China., Lin H; Department of Orthopedic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian Province, China.; Department of Orthopedic Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian Province, China., Xu J; Department of Orthopedic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian Province, China. 457884651@qq.com.; Department of Orthopedic Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian Province, China. 457884651@qq.com., Lin S; Department of Orthopedic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian Province, China. linshishui1@fjmu.edu.cn.; Department of Orthopedic Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian Province, China. linshishui1@fjmu.edu.cn.
Source: Scientific reports [Sci Rep] 2026 May 07; Vol. 16 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-48653-6