Symptom-guided approach to central nervous system complications in allogeneic hematopoietic cell transplant recipients: Best practice recommendations from the EBMT Practice Harmonisation and Guidelines committee.

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Title: Symptom-guided approach to central nervous system complications in allogeneic hematopoietic cell transplant recipients: Best practice recommendations from the EBMT Practice Harmonisation and Guidelines committee.
Authors: Velasco R; Department of Neurology, Neuro-oncology Unit, Institut Català d'Oncologia - Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. rvelascof@bellvitgehospital.cat.; Department of Cell Biology, Physiology, and Immunology, Universitat Autònoma de Barcelona, Bellaterra, & CIBERNED, Barcelona, Spain. rvelascof@bellvitgehospital.cat.; Complications Working Party, EBMT, Paris, France. rvelascof@bellvitgehospital.cat., Schmidt-Hieber M; Clinic for Oncology, Hematology, Pneumology, Nephrology and Diabetology, Medical University Lausitz - Carl Thiem (MUL-CT), Cottbus, Germany.; Infectious Diseases Working Party, EBMT, Leiden, Netherlands., Penack O; Complications Working Party, EBMT, Paris, France.; Department of Hematology, Oncology and Tumorimmunology, Charite University Hospital, Free University of Berlin and Humboldt University of Berlin, Berlin, Germany.; National Center for Tumor Diseases, Berlin, Germany., Averbuch D; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Hadassah Medical Center, Jerusalem, Israel., Balaguer-Roselló A; Department of Hematology, Hospital Universitari I Politècnic la Fe, València, Spain., Baccelli F; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Bataller L; Department of Neurology, Instituto Valenciano de Oncología, Valencia, Spain.; Department of Medicine, University of Valencia, Valencia, Spain., Cesaro S; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Briani C; Department of Neurosciences, Neurology Unit, University of Padova, Padova, Italy., de la Cámara R; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Hematology Department, Hospital de la Princesa, Madrid, Spain., Huehnchen P; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department for Neurology with Experimental Neurology, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Cluster of Excellence, Berlin, Germany., de Silva T; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Division of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Sheffield, UK., Mussetti A; Complications Working Party, EBMT, Paris, France.; Clinical Hematology Department, Institut Català d'Oncologia, Hospitalet de Llobregat, Barcelona, Spain.; Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain., Ljungman P; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Dept. of Cellular Therapy and Allogeneic Stem Cell Transplantation, Comprehensive Cancer Center, and Dept. of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine Huddinge, Karolinska Institutet (KI), Stockholm, Sweden., Perić Z; Complications Working Party, EBMT, Paris, France.; Department of Hematology, University Hospital Centre Rijeka, Faculty of Medicine, University of Rijeka, Rijeka, Croatia., Mikulska M; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.; IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy., Polushin A; R.M. Gorbacheva Research Institute, Pavlov University, St, Petersburg, Russia., Navarro Ortega D; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain., Pons-Escoda A; Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.; Department of Neuro-Radiology, Neuro-oncology Unit, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Neofytos D; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Division of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland., Schoemans H; Complications Working Party, EBMT, Paris, France.; Department of Hematology, University Hospitals Leuven, Leuven, Belgium.; Department of Public Health and Primary Care, ACCENT VV, KU Leuven - University of Leuven, Leuven, Belgium., Piñana JL; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Department of Hematology. Hospital Clínico Universitario of Valencia, Valencia, Spain.; INCLIVA, Biomedical Research Institute, Valencia, Spain., Onida F; Practice Harmonisation and Guidelines Committee, EBMT, Barcelona, Spain.; Haematology and BMT Unit, ASST Fatebenefratelli-Sacco, Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Ruggeri A; Practice Harmonisation and Guidelines Committee, EBMT, Barcelona, Spain.; Cellular Therapy & Immunobiology Working Party, EBMT, Leiden, Netherlands.; Hematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy., Sanchez-Ortega I; Practice Harmonisation and Guidelines Committee, EBMT, Barcelona, Spain.; Medical Officer, EBMT, Executive Office, EBMT, Barcelona, Spain., Yakoub-Agha I; Practice Harmonisation and Guidelines Committee, EBMT, Barcelona, Spain.; Centre Hospitalier Universitaire de Lille, University of Lille, INSERM U1286, Lille, France., Styczynski J; Infectious Diseases Working Party, EBMT, Leiden, Netherlands.; Department of Pediatric Hematology, Oncology, Immunology and Transplantology, Collegium Medicum, Nicolaus Copernicus University Torun, University Hospital, Bydgoszcz, Poland.
Source: Bone marrow transplantation [Bone Marrow Transplant] 2026 Jul; Vol. 61 (7), pp. 805-815. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Practice Guideline; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8702459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5365 (Electronic) Linking ISSN: 02683369 NLM ISO Abbreviation: Bone Marrow Transplant Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5365
DOI:10.1038/s41409-026-02866-5