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A broadly-neutralizing antibody against Orthoebolavirus glycoprotein that potentiates the breadth and neutralization of other antibodies.

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Title: A broadly-neutralizing antibody against Orthoebolavirus glycoprotein that potentiates the breadth and neutralization of other antibodies.
Authors: Donnellan FR; Department of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, Old Road Campus Research Building, University of Oxford, Oxford, UK.; Department of Paediatrics, University of Oxford, Oxford, UK., Rayaprolu V; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Pacific Northwest Cryo-EM Center, Oregon Health and Sciences University, Portland, OR, USA., Rijal P; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, University of Oxford, Oxford, UK.; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK., O'Dowd V; UCB Pharma, Slough, UK., Parvate A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA., Callaway H; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Chemistry & Biochemistry Building, Montana State University, Bozeman, MT, USA., Hariharan C; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Parekh D; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Hui S; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Shaffer KCL; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Avalos RD; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Hastie KM; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Schimanski L; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK., Müller-Kräuter H; Institute of Virology, Philipps University Marburg, Marburg, Germany., Strecker T; Institute of Virology, Philipps University Marburg, Marburg, Germany., Balaram A; Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA., Halfmann P; Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA., Saphire EO; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Lightwood DJ; UCB Pharma, Slough, UK., Townsend AR; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, University of Oxford, Oxford, UK.; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK., Draper SJ; Department of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; The Jenner Institute, Old Road Campus Research Building, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; Department of Paediatrics, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.
Source: Npj viruses [Npj Viruses] 2026 May 07; Vol. 4 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio, Springer Nature Country of Publication: England NLM ID: 9918716188906676 Publication Model: Electronic Cited Medium: Internet ISSN: 2948-1767 (Electronic) Linking ISSN: 29481767 NLM ISO Abbreviation: Npj Viruses Subsets: PubMed not MEDLINE
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  Data: A broadly-neutralizing antibody against Orthoebolavirus glycoprotein that potentiates the breadth and neutralization of other antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Donnellan+FR%22">Donnellan FR</searchLink>; Department of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, Old Road Campus Research Building, University of Oxford, Oxford, UK.; Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rayaprolu+V%22">Rayaprolu V</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Pacific Northwest Cryo-EM Center, Oregon Health and Sciences University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Rijal+P%22">Rijal P</searchLink>; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, University of Oxford, Oxford, UK.; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22O'Dowd+V%22">O'Dowd V</searchLink>; UCB Pharma, Slough, UK.<br /><searchLink fieldCode="AU" term="%22Parvate+A%22">Parvate A</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Callaway+H%22">Callaway H</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Chemistry & Biochemistry Building, Montana State University, Bozeman, MT, USA.<br /><searchLink fieldCode="AU" term="%22Hariharan+C%22">Hariharan C</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Parekh+D%22">Parekh D</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hui+S%22">Hui S</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Shaffer+KCL%22">Shaffer KCL</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Avalos+RD%22">Avalos RD</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hastie+KM%22">Hastie KM</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schimanski+L%22">Schimanski L</searchLink>; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Müller-Kräuter+H%22">Müller-Kräuter H</searchLink>; Institute of Virology, Philipps University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Strecker+T%22">Strecker T</searchLink>; Institute of Virology, Philipps University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Balaram+A%22">Balaram A</searchLink>; Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Halfmann+P%22">Halfmann P</searchLink>; Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Saphire+EO%22">Saphire EO</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lightwood+DJ%22">Lightwood DJ</searchLink>; UCB Pharma, Slough, UK.<br /><searchLink fieldCode="AU" term="%22Townsend+AR%22">Townsend AR</searchLink>; CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, University of Oxford, Oxford, UK.; MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Draper+SJ%22">Draper SJ</searchLink>; Department of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; The Jenner Institute, Old Road Campus Research Building, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.; Department of Paediatrics, University of Oxford, Oxford, UK. simon.draper@paediatrics.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229918716188906676%22">Npj viruses</searchLink> [Npj Viruses] 2026 May 07; Vol. 4 (1). <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%2C+Springer+Nature%22">Nature Portfolio, Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918716188906676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2948-1767 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2229481767%22">29481767 </searchLink><i>NLM ISO Abbreviation: </i>Npj Viruses <i>Subsets: </i>PubMed not MEDLINE
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