Stiripentol induces ER stress and pyroptosis in pancreatic cancer cells under metabolic stress by dysregulating SFAs/UFAs homeostasis.

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Title: Stiripentol induces ER stress and pyroptosis in pancreatic cancer cells under metabolic stress by dysregulating SFAs/UFAs homeostasis.
Authors: Ding J; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, No. 1800 Yuntai Rd, Shanghai, 200123, China., Pan J; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, No. 1800 Yuntai Rd, Shanghai, 200123, China.; Hubei University of Medicine, Shiyan, Hubei Province, 442000, China., Xue W; Tongji University School of Medicine, No. 500 Zhennan Rd, Shanghai, 200331, China., Ying S; Tongji University School of Medicine, No. 500 Zhennan Rd, Shanghai, 200331, China., Zuo S; Tongji University School of Medicine, No. 500 Zhennan Rd, Shanghai, 200331, China., Xia R; Tongji University School of Medicine, No. 500 Zhennan Rd, Shanghai, 200331, China., Li Y; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, No. 1800 Yuntai Rd, Shanghai, 200123, China., Quan M; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, No. 1800 Yuntai Rd, Shanghai, 200123, China. mquan@tongji.edu.cn.
Source: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2026 May 08; Vol. 49 (4). Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Electronic Cited Medium: Internet ISSN: 2211-3436 (Electronic) Linking ISSN: 22113428 NLM ISO Abbreviation: Cell Oncol (Dordr) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2211-3436
DOI:10.1007/s13402-026-01205-6