Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial.
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| Title: | Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial. |
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| Authors: | Xiong Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China., Che F; Department of Neurology, Linyi People's Hospital, Linyi, China., Wang H; Department of Neurology, Linyi People's Hospital, Linyi, China., Hao M; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Nguyen TN; Department of Neurology and Radiology, Boston Medical Center, Boston, Massachusetts., Fisher M; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Jin A; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China., Cao Z; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Wang Z; Department of Neurology, Linyi People's Hospital, Linyi, China., Yao X; Department of Neurology, First People's Hospital of Chenzhou, Chenzhou, China., Feng G; Department of Neurology, First People's Hospital of Chenzhou, Chenzhou, China., Xu Y; Department of Neurology, Linyi Central Hospital, Linyi, China., Guo S; Department of Neurology, Linyi Central Hospital, Linyi, China., Qin H; Department of Neurology, Zaozhuang Municipal Hospital, Zaozhuang, China., Huang X; Department of Neurology, First Affiliated Hospital of Wannan Medical College, Wuhu, China., Xu J; Department of Neurology, People's Hospital of Queshan, Zhumadian, China., Chen Z; Department of Neurological Intervention and Neurological Intensive Care, Dalian Municipal Central Hospital, Dalian, China., Yuan J; Department of Neurology, Daxing Teaching Hospital, Capital Medical University, Beijing, China., Li W; Department of Neurology, Heze Municipal Hospital, Heze, China., Hu W; Department of Neurology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Feng X; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Zong L; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Ye W; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China., Duan C; Department of Neurology, Daxing Teaching Hospital, Capital Medical University, Beijing, China., Wang L; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Wu S; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Campbell BCV; Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Wang Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China. |
| Corporate Authors: | TNK-PLUS Investigators |
| Source: | JAMA [JAMA] 2026 Jun 02; Vol. 335 (21), pp. 1849-1858. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III; Equivalence Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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