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Deep learning insights into β-lactamase dynamics and resistance evolution.

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Title: Deep learning insights into β-lactamase dynamics and resistance evolution.
Authors: Gu J; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K., Gao L; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K., Chen S; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K., Xu M; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K., Goyal J; Department of Biophysics, University of Delhi, New Delhi 110021, India., Haider R; Institute of Structure and Molecular Biology, School of Natural Sciences, Birkbeck University of London, London WC1E 7HX, U.K., Attana F; Prince Fahd Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk 71491, Saudi Arabia., Alzahrani ORA; Department of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia., Bonomo RA; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Centre, Cleveland, OH, U.S.A.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; CWRU-Cleveland VAMC Centre for Antimicrobial Resistance and Epidemiology (Case VA CARES) Cleveland, OH, U.S.A., Haider S; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.; Prince Fahd Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk 71491, Saudi Arabia.
Source: The Biochemical journal [Biochem J] 2026 Jun 03; Vol. 483 (6), pp. 861-879.
Publication Type: Journal Article; Review
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deep learning insights into β-lactamase dynamics and resistance evolution.
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  Data: <searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.<br /><searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.<br /><searchLink fieldCode="AU" term="%22Goyal+J%22">Goyal J</searchLink>; Department of Biophysics, University of Delhi, New Delhi 110021, India.<br /><searchLink fieldCode="AU" term="%22Haider+R%22">Haider R</searchLink>; Institute of Structure and Molecular Biology, School of Natural Sciences, Birkbeck University of London, London WC1E 7HX, U.K.<br /><searchLink fieldCode="AU" term="%22Attana+F%22">Attana F</searchLink>; Prince Fahd Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk 71491, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alzahrani+ORA%22">Alzahrani ORA</searchLink>; Department of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Bonomo+RA%22">Bonomo RA</searchLink>; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Centre, Cleveland, OH, U.S.A.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, U.S.A.; CWRU-Cleveland VAMC Centre for Antimicrobial Resistance and Epidemiology (Case VA CARES) Cleveland, OH, U.S.A.<br /><searchLink fieldCode="AU" term="%22Haider+S%22">Haider S</searchLink>; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, London WC1N 1AX, U.K.; Prince Fahd Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk 71491, Saudi Arabia.
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              Text: 2026 Jun 03
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