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Population Pharmacokinetic/Pharmacodynamic Modeling of Therapeutic Enzymes in Lysosomal Storage Diseases.

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Title: Population Pharmacokinetic/Pharmacodynamic Modeling of Therapeutic Enzymes in Lysosomal Storage Diseases.
Authors: Barzel I; Department of Hospital Pharmacy, Erasmus MC, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. i.barzel@erasmusmc.nl.; Rotterdam Clinical Pharmacometrics Group, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands. i.barzel@erasmusmc.nl., van der Ploeg AT; Department of Pediatrics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Pijnappel WWMP; Department of Pediatrics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Kuy PHM; Department of Hospital Pharmacy, Erasmus MC, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands., van den Hout JMP; Department of Pediatrics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Preijers T; Department of Hospital Pharmacy, Erasmus MC, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Rotterdam Clinical Pharmacometrics Group, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 May; Vol. 65 (5), pp. 647-664. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article; Review; Systematic Review
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Population Pharmacokinetic/Pharmacodynamic Modeling of Therapeutic Enzymes in Lysosomal Storage Diseases.
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  Data: <searchLink fieldCode="AU" term="%22Barzel+I%22">Barzel I</searchLink>; Department of Hospital Pharmacy, Erasmus MC, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. i.barzel@erasmusmc.nl.; Rotterdam Clinical Pharmacometrics Group, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands. i.barzel@erasmusmc.nl.<br /><searchLink fieldCode="AU" term="%22van+der+Ploeg+AT%22">van der Ploeg AT</searchLink>; Department of Pediatrics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pijnappel+WWMP%22">Pijnappel WWMP</searchLink>; Department of Pediatrics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Kuy+PHM%22">van der Kuy PHM</searchLink>; Department of Hospital Pharmacy, Erasmus MC, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Hout+JMP%22">van den Hout JMP</searchLink>; Department of Pediatrics, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; Center for Lysosomal and Metabolic Diseases, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Preijers+T%22">Preijers T</searchLink>; Department of Hospital Pharmacy, Erasmus MC, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.; Rotterdam Clinical Pharmacometrics Group, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%227606849%22">Clinical pharmacokinetics</searchLink> [Clin Pharmacokinet] 2026 May; Vol. 65 (5), pp. 647-664. <i>Date of Electronic Publication: </i>2026 May 08.
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        Value: 10.1007/s40262-026-01636-2
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        Text: English
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      – TitleFull: Population Pharmacokinetic/Pharmacodynamic Modeling of Therapeutic Enzymes in Lysosomal Storage Diseases.
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              Text: 2026 May
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