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Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies.

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Title: Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies.
Authors: Chen LY; University of Oxford, Oxford, United Kingdom., Aleman A; Icahn School of Medicine at Mount Sinai, New York, New York, United States., Larrayoz M; CIMA, Pamplona, Spain., Chiu H; Bristol-Myers Squibb, Summit, New Jersey, United States., Zhao J; Bristol-Myers Squibb, Summit, New Jersey, United States., Van Oekelen O; Icahn School of Medicine at Mount Sinai, New York, New York, United States., Kelly G; Icahn School of Medicine at Mount Sinai, New York, New York, United States., Kim-Schulze S; Mount Sinai School of Medicine, New york, New York, United States., Lagana A; Icahn School of Medicine at Mount Sinai, New York, New York, United States., Jagannath S; Mt. Sinai Medical Center, New York, New York, United States., Chow TT; Bristol-Myers Squibb, Summit, New Jersey, United States., Lozano T; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain., Lasarte JJ; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain., Hamley JC; University of Oxford, Oxford, United Kingdom., Baker W; University of Oxford, Oxford, United Kingdom., Ebert BL; Dana-Farber Cancer Institute, Boston, Massachusetts, United States., Oppermann U; University of Oxford, Oxford, United Kingdom., Amatangelo MD; Bristol-Myers Squibb, Madison, New Jersey, United States., Gandhi AK; Bristol-Myers Squibb, Summit, New Jersey, United States., Hagner PR; Bristol-Myers Squibb, Summit, New Jersey, United States., Martínez-Climent JA; Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain., Gooding S; University of Oxford, Oxford, United Kingdom., Milne TA; University of Oxford, Oxford, United Kingdom., Parekh S; Icahn School of Medicine at Mount Sinai, NEW YORK, New York, United States.
Source: Blood [Blood] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies.
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  Data: <searchLink fieldCode="AU" term="%22Chen+LY%22">Chen LY</searchLink>; University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Aleman+A%22">Aleman A</searchLink>; Icahn School of Medicine at Mount Sinai, New York, New York, United States.<br /><searchLink fieldCode="AU" term="%22Larrayoz+M%22">Larrayoz M</searchLink>; CIMA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Chiu+H%22">Chiu H</searchLink>; Bristol-Myers Squibb, Summit, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Bristol-Myers Squibb, Summit, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Van+Oekelen+O%22">Van Oekelen O</searchLink>; Icahn School of Medicine at Mount Sinai, New York, New York, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+G%22">Kelly G</searchLink>; Icahn School of Medicine at Mount Sinai, New York, New York, United States.<br /><searchLink fieldCode="AU" term="%22Kim-Schulze+S%22">Kim-Schulze S</searchLink>; Mount Sinai School of Medicine, New york, New York, United States.<br /><searchLink fieldCode="AU" term="%22Lagana+A%22">Lagana A</searchLink>; Icahn School of Medicine at Mount Sinai, New York, New York, United States.<br /><searchLink fieldCode="AU" term="%22Jagannath+S%22">Jagannath S</searchLink>; Mt. Sinai Medical Center, New York, New York, United States.<br /><searchLink fieldCode="AU" term="%22Chow+TT%22">Chow TT</searchLink>; Bristol-Myers Squibb, Summit, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Lozano+T%22">Lozano T</searchLink>; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Lasarte+JJ%22">Lasarte JJ</searchLink>; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Hamley+JC%22">Hamley JC</searchLink>; University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Baker+W%22">Baker W</searchLink>; University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ebert+BL%22">Ebert BL</searchLink>; Dana-Farber Cancer Institute, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Oppermann+U%22">Oppermann U</searchLink>; University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Amatangelo+MD%22">Amatangelo MD</searchLink>; Bristol-Myers Squibb, Madison, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Gandhi+AK%22">Gandhi AK</searchLink>; Bristol-Myers Squibb, Summit, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Hagner+PR%22">Hagner PR</searchLink>; Bristol-Myers Squibb, Summit, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Martínez-Climent+JA%22">Martínez-Climent JA</searchLink>; Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Gooding+S%22">Gooding S</searchLink>; University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Milne+TA%22">Milne TA</searchLink>; University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Parekh+S%22">Parekh S</searchLink>; Icahn School of Medicine at Mount Sinai, NEW YORK, New York, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603509 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0020 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200064971%22">00064971 </searchLink><i>NLM ISO Abbreviation: </i>Blood <i>Subsets: </i>MEDLINE
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        Value: 10.1182/blood.2025030891
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        Text: English
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      – TitleFull: Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies.
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              Text: 2026 May 08
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