Functional evaluation of TRPC6 missense variants in cancer patients via molecular docking analysis compared with patch Clamp electrophysiology.

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Bibliographic Details
Title: Functional evaluation of TRPC6 missense variants in cancer patients via molecular docking analysis compared with patch Clamp electrophysiology.
Authors: Wu Y; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, P. R. China., Sun X; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Reddy JS; The Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, USA., Advani PP; The Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USA., Boddicker NJ; Division of Computational Biology, Mayo Clinic, Rochester, Minnesota, USA., Cerhan JR; Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA., Villarraga HR; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Asirvatham SJ; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Wang RX; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, P. R. China., Lee HC; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Norton N; The Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA., Zanchi FB; Bioinformatics and Medicinal Chemistry Laboratory, Oswaldo Cruz Rondônia Foundation, Porto Velho, Rondônia, Brazil; National Institute of Epidemiology in the Western Amazon, Porto Velho, Rondônia, Brazil; Postgraduate Program in Experimental Biology, Federal University of Rondônia, Porto Velho, Rondônia, Brazil; Doctoral Program in Sciences - IOC/Fiocruz Rondônia Cooperation: Computational Biology and Systems, Porto Velho, Rondônia, Brazil., Lu T; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: lu.tong@mayo.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Jun; Vol. 302 (6), pp. 113124. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2026.113124