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Functional evaluation of TRPC6 missense variants in cancer patients via molecular docking analysis compared with patch Clamp electrophysiology.

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Title: Functional evaluation of TRPC6 missense variants in cancer patients via molecular docking analysis compared with patch Clamp electrophysiology.
Authors: Wu Y; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, P. R. China., Sun X; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Reddy JS; The Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, USA., Advani PP; The Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USA., Boddicker NJ; Division of Computational Biology, Mayo Clinic, Rochester, Minnesota, USA., Cerhan JR; Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA., Villarraga HR; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Asirvatham SJ; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Wang RX; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, P. R. China., Lee HC; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA., Norton N; The Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA., Zanchi FB; Bioinformatics and Medicinal Chemistry Laboratory, Oswaldo Cruz Rondônia Foundation, Porto Velho, Rondônia, Brazil; National Institute of Epidemiology in the Western Amazon, Porto Velho, Rondônia, Brazil; Postgraduate Program in Experimental Biology, Federal University of Rondônia, Porto Velho, Rondônia, Brazil; Doctoral Program in Sciences - IOC/Fiocruz Rondônia Cooperation: Computational Biology and Systems, Porto Velho, Rondônia, Brazil., Lu T; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: lu.tong@mayo.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Jun; Vol. 302 (6), pp. 113124. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Functional evaluation of TRPC6 missense variants in cancer patients via molecular docking analysis compared with patch Clamp electrophysiology.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+JS%22">Reddy JS</searchLink>; The Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Advani+PP%22">Advani PP</searchLink>; The Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Boddicker+NJ%22">Boddicker NJ</searchLink>; Division of Computational Biology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Cerhan+JR%22">Cerhan JR</searchLink>; Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Villarraga+HR%22">Villarraga HR</searchLink>; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Asirvatham+SJ%22">Asirvatham SJ</searchLink>; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Wang+RX%22">Wang RX</searchLink>; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lee+HC%22">Lee HC</searchLink>; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Norton+N%22">Norton N</searchLink>; The Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Zanchi+FB%22">Zanchi FB</searchLink>; Bioinformatics and Medicinal Chemistry Laboratory, Oswaldo Cruz Rondônia Foundation, Porto Velho, Rondônia, Brazil; National Institute of Epidemiology in the Western Amazon, Porto Velho, Rondônia, Brazil; Postgraduate Program in Experimental Biology, Federal University of Rondônia, Porto Velho, Rondônia, Brazil; Doctoral Program in Sciences - IOC/Fiocruz Rondônia Cooperation: Computational Biology and Systems, Porto Velho, Rondônia, Brazil.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: lu.tong@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 Jun; Vol. 302 (6), pp. 113124. <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2026.113124
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              Text: 2026 Jun
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