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A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy.

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Title: A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy.
Authors: Özsan Ç; Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Bern, Switzerland.; Department of Chemistry, University of York, York, UK., Schäfer AB; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden., Akhir A; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India., Aning OA; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden., Fulgencio S; Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Maitra R; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India., Rani R; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden., Saxena D; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India., Westerlund F; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden., Chopra S; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Wenzel M; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden. wenzelm@chalmers.se.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden. wenzelm@chalmers.se., Frei A; Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Bern, Switzerland. angelo.frei@york.ac.uk.; Department of Chemistry, University of York, York, UK. angelo.frei@york.ac.uk.
Source: Npj antimicrobials and resistance [NPJ Antimicrob Resist] 2026 May 08; Vol. 4 (1). Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918804282606676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-8745 (Electronic) Linking ISSN: 27318745 NLM ISO Abbreviation: NPJ Antimicrob Resist Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Özsan+Ç%22">Özsan Ç</searchLink>; Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Bern, Switzerland.; Department of Chemistry, University of York, York, UK.<br /><searchLink fieldCode="AU" term="%22Schäfer+AB%22">Schäfer AB</searchLink>; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Akhir+A%22">Akhir A</searchLink>; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Aning+OA%22">Aning OA</searchLink>; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Fulgencio+S%22">Fulgencio S</searchLink>; Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Maitra+R%22">Maitra R</searchLink>; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Rani+R%22">Rani R</searchLink>; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Saxena+D%22">Saxena D</searchLink>; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Westerlund+F%22">Westerlund F</searchLink>; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Chopra+S%22">Chopra S</searchLink>; Department of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.<br /><searchLink fieldCode="AU" term="%22Wenzel+M%22">Wenzel M</searchLink>; Division of Molecular Bioscience, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden. wenzelm@chalmers.se.; Center for Antibiotic Resistance Research in Gothenburg (CARe), Gothenburg, Sweden. wenzelm@chalmers.se.<br /><searchLink fieldCode="AU" term="%22Frei+A%22">Frei A</searchLink>; Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Bern, Switzerland. angelo.frei@york.ac.uk.; Department of Chemistry, University of York, York, UK. angelo.frei@york.ac.uk.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918804282606676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2731-8745 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227318745%22">27318745 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Antimicrob Resist <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 May 08
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