Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.

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Title: Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.
Authors: Carlini NA; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Hanson BE; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Ruple BA; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Craig JC; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Fermoyle CC; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Faculty of Medicine and Health, University of Sydney, Australia., McKenzie AI; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Bisconti AV; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Pelka EZ; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Supiano MA; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States., Tuday E; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Division of Cardiology, Department of Internal Medicine, The University of Utah School of Medicine, Salt Lake City, UT, United States., Richardson RS; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States., Drummond MJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, United States; Molecular Medicine Program, University of Utah, Salt Lake City, UT, United States., Rajasekaran NS; Cardiac Aging and Redox Signaling Laboratory, Molecular and Cellular Pathology, Department of Pathology/Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, United States., Broxterman RM; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Trinity JD; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States. Electronic address: joel.trinity@hscutah.edu.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 May 07; Vol. 254, pp. 827-841. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-4596
DOI:10.1016/j.freeradbiomed.2026.05.282