Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.

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Title: Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.
Authors: Pourzal R; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA. Electronic address: Robin_Pourzal@rush.edu., Agarwal P; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Leurgans SE; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA., McCarthy SM; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA., Hall DJ; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA., McDevitt CA; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia., Ganio K; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia., Ayton S; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia., Bush AI; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia., Grodstein F; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., James BD; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Agrawal S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA., Hallab NJ; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA; Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA., Jacobs JJ; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Source: Acta biomaterialia [Acta Biomater] 2026 Jun; Vol. 217, pp. 750-760. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1878-7568
DOI:10.1016/j.actbio.2026.05.006