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Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.

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Title: Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.
Authors: Pourzal R; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA. Electronic address: Robin_Pourzal@rush.edu., Agarwal P; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Leurgans SE; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA., McCarthy SM; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA., Hall DJ; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA., McDevitt CA; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia., Ganio K; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia., Ayton S; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia., Bush AI; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia., Grodstein F; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., James BD; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Agrawal S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA., Hallab NJ; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA; Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA., Jacobs JJ; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Source: Acta biomaterialia [Acta Biomater] 2026 Jun; Vol. 217, pp. 750-760. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE
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  Data: Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.
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  Data: <searchLink fieldCode="AU" term="%22Pourzal+R%22">Pourzal R</searchLink>; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA. Electronic address: Robin_Pourzal@rush.edu.<br /><searchLink fieldCode="AU" term="%22Agarwal+P%22">Agarwal P</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Leurgans+SE%22">Leurgans SE</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+SM%22">McCarthy SM</searchLink>; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Hall+DJ%22">Hall DJ</searchLink>; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22McDevitt+CA%22">McDevitt CA</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Ganio+K%22">Ganio K</searchLink>; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Ayton+S%22">Ayton S</searchLink>; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Bush+AI%22">Bush AI</searchLink>; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Grodstein+F%22">Grodstein F</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22James+BD%22">James BD</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Agrawal+S%22">Agrawal S</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Hallab+NJ%22">Hallab NJ</searchLink>; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA; Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+JJ%22">Jacobs JJ</searchLink>; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
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  Data: <searchLink fieldCode="JN" term="%22101233144%22">Acta biomaterialia</searchLink> [Acta Biomater] 2026 Jun; Vol. 217, pp. 750-760. <i>Date of Electronic Publication: </i>2026 May 07.
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        Value: 10.1016/j.actbio.2026.05.006
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        Text: English
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              Text: 2026 Jun
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