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IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes.

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Title: IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes.
Authors: Liu J; Department of Rheumatology, Peking University First Hospital, Beijing, China., Xie W; Department of Rheumatology, Peking University First Hospital, Beijing, China., Cao Y; Department of Orthopedics, Peking University First Hospital, Beijing, China., Zhang L; Department of Orthopedics, Beijing Jishuitan Hospital, Beijing, China., Geng Y; Department of Rheumatology, Peking University First Hospital, Beijing, China., Zhang Z; Department of Rheumatology, Peking University First Hospital, Beijing, China. zhuoli.zhang@126.com.; Department of Rheumatology and Clinical Immunology, Peking University First Hospital, No.8, Xishiku Street, West District, Beijing, 100034, China. zhuoli.zhang@126.com.
Source: Arthritis research & therapy [Arthritis Res Ther] 2026 May 09; Vol. 28 (1). Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes.
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  Data: <searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Rheumatology, Peking University First Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xie+W%22">Xie W</searchLink>; Department of Rheumatology, Peking University First Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Department of Orthopedics, Peking University First Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Orthopedics, Beijing Jishuitan Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Geng+Y%22">Geng Y</searchLink>; Department of Rheumatology, Peking University First Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Rheumatology, Peking University First Hospital, Beijing, China. zhuoli.zhang@126.com.; Department of Rheumatology and Clinical Immunology, Peking University First Hospital, No.8, Xishiku Street, West District, Beijing, 100034, China. zhuoli.zhang@126.com.
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  Data: <searchLink fieldCode="JN" term="%22101154438%22">Arthritis research & therapy</searchLink> [Arthritis Res Ther] 2026 May 09; Vol. 28 (1). <i>Date of Electronic Publication: </i>2026 May 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101154438 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1478-6362 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214786354%22">14786354 </searchLink><i>NLM ISO Abbreviation: </i>Arthritis Res Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13075-026-03827-5
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        Text: English
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      – TitleFull: IRE1/p‑JNK/NRF2 axis-mediated GPX4 upregulation underlies ferroptosis resistance in rheumatoid arthritis fibroblast-like synoviocytes.
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              Text: 2026 May 09
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