Rational design of a novel engineered factor X with chimeric activation peptide as bypassing agent for hemophilia.

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Bibliographic Details
Title: Rational design of a novel engineered factor X with chimeric activation peptide as bypassing agent for hemophilia.
Authors: Tarantino R; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Bunce MW; Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Tonetto E; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Testa MF; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Castaman G; Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Florence, Italy., Bernardi F; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Pinotti M; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: pnm@unife.it., Camire RM; Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: rcamire@pennmedicine.upenn.edu., Branchini A; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: brnlss@unife.it.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7836
DOI:10.1016/j.jtha.2026.04.027