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Rational design of a novel engineered factor X with chimeric activation peptide as bypassing agent for hemophilia.

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Title: Rational design of a novel engineered factor X with chimeric activation peptide as bypassing agent for hemophilia.
Authors: Tarantino R; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Bunce MW; Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Tonetto E; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Testa MF; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Castaman G; Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Florence, Italy., Bernardi F; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Pinotti M; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: pnm@unife.it., Camire RM; Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: rcamire@pennmedicine.upenn.edu., Branchini A; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: brnlss@unife.it.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rational design of a novel engineered factor X with chimeric activation peptide as bypassing agent for hemophilia.
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  Data: <searchLink fieldCode="AU" term="%22Tarantino+R%22">Tarantino R</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Bunce+MW%22">Bunce MW</searchLink>; Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Tonetto+E%22">Tonetto E</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Testa+MF%22">Testa MF</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Castaman+G%22">Castaman G</searchLink>; Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+F%22">Bernardi F</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Pinotti+M%22">Pinotti M</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: pnm@unife.it.<br /><searchLink fieldCode="AU" term="%22Camire+RM%22">Camire RM</searchLink>; Division of Hematology and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: rcamire@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Branchini+A%22">Branchini A</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: brnlss@unife.it.
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  Data: <searchLink fieldCode="JN" term="%22101170508%22">Journal of thrombosis and haemostasis : JTH</searchLink> [J Thromb Haemost] 2026 May 08. <i>Date of Electronic Publication: </i>2026 May 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170508 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7836 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215387836%22">15387836 </searchLink><i>NLM ISO Abbreviation: </i>J Thromb Haemost <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jtha.2026.04.027
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      – Code: eng
        Text: English
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      – TitleFull: Rational design of a novel engineered factor X with chimeric activation peptide as bypassing agent for hemophilia.
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            NameFull: Tarantino R
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            – D: 08
              M: 05
              Text: 2026 May 08
              Type: published
              Y: 2026
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