Dose-dependent protective effects of Tripterygium wilfordii glycosides on joint and lung injury and gut microbiota remodeling in collagen-induced arthritis rats.

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Title: Dose-dependent protective effects of Tripterygium wilfordii glycosides on joint and lung injury and gut microbiota remodeling in collagen-induced arthritis rats.
Authors: Qi S; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.; First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China., Xing Q; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.; Huixian County Hospital of Traditional Chinese Medicine, Xinxiang, Henan, China., Gong X; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China., Jiang Y; First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; Department of Gastroenterology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China., Zhao Z; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China., Feng Z; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.; First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China., Jiao S; Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Zhengzhou, Henan, China.; The Second Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China., Wang C; Henan Provincial Hospital of Traditional Chinese Medicine (The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Zhengzhou, Henan, China.; The Second Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China., Li S; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China., Li H; Department of Rheumatology and Immunology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.; First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Apr 23; Vol. 17, pp. 1783503. Date of Electronic Publication: 2026 Apr 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1663-9812
DOI:10.3389/fphar.2026.1783503