DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.

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Title: DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.
Authors: Liu D; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany. Electronic address: dan.liu@dzne.de., Talevi V; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Tavares JF; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Wang R; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Imtiaz MA; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Melas K; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Teumer A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, 17475, Germany., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489, Greifswald, Germany., Hillary RF; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., Vojinovic D; Molecular Epidemiology, Department of Biomedical Data Science, Leiden University Medical Centre, 233 ZA, Leiden, the Netherlands., Beekman M; Molecular Epidemiology, Department of Biomedical Data Science, Leiden University Medical Centre, 233 ZA, Leiden, the Netherlands., Armstrong NJ; Mathematics and Statistics, Curtin University, 6845, Perth, Australia., Estrada S; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany; Artificial Intelligence in Medical Imaging, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Völzke H; German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, 17475, Germany; Institute for Community Medicine, University Medicine Greifswald, 17489, Greifswald, Germany., Bülow R; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17489, Greifswald, Germany., Royle NA; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK; Brain Research Imaging Centre, The University of Edinburgh, Edinburgh, EH8 9AB, UK., Wardlaw JM; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK; Brain Research Imaging Centre, The University of Edinburgh, Edinburgh, EH8 9AB, UK., Wen W; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia., Sachdev PS; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia., Mather KA; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia., Slagboom PE; Molecular Epidemiology, Department of Biomedical Data Science, Leiden University Medical Centre, 233 ZA, Leiden, the Netherlands; Max Planck Institute for Biology of Ageing, 50931, Cologne, Germany., Cox SR; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489, Greifswald, Germany; German Centre for Neurodegenerative Diseases (DZNE), Partner Site Rostock/Greifswald, 17489, Greifswald, Germany., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA; The Framingham Heart Study, Framingham, MA, 01701, USA., Aziz NA; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany; Department of Neurology, Faculty of Medicine, University of Bonn, 53127, Bonn, Germany., Breteler MMB; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, 53127, Bonn, Germany.
Source: EBioMedicine [EBioMedicine] 2026 Jun; Vol. 128, pp. 106289. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3964
DOI:10.1016/j.ebiom.2026.106289