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Exosomal NEAT1 from tumor stem cells induces SIRPA+ macrophages to enhance immune evasion and glioblastoma progression via upregulating the HSP90B1/STAT3 axis.

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Title: Exosomal NEAT1 from tumor stem cells induces SIRPA+ macrophages to enhance immune evasion and glioblastoma progression via upregulating the HSP90B1/STAT3 axis.
Authors: Yin N; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Zhang Z; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Xia F; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Zhang X; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Li Z; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Zhong T; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Pan J; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Liang G; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Huang D; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Dai X; Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China., Dong J; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. dongjun@suda.edu.cn.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 May 11; Vol. 45 (1). Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exosomal NEAT1 from tumor stem cells induces SIRPA<superscript>+</superscript> macrophages to enhance immune evasion and glioblastoma progression via upregulating the HSP90B1/STAT3 axis.
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  Data: <searchLink fieldCode="AU" term="%22Yin+N%22">Yin N</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Xia+F%22">Xia F</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Zhong+T%22">Zhong T</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Pan+J%22">Pan J</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Liang+G%22">Liang G</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Huang+D%22">Huang D</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.<br /><searchLink fieldCode="AU" term="%22Dai+X%22">Dai X</searchLink>; Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Dong+J%22">Dong J</searchLink>; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. dongjun@suda.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228308647%22">Journal of experimental & clinical cancer research : CR</searchLink> [J Exp Clin Cancer Res] 2026 May 11; Vol. 45 (1). <i>Date of Electronic Publication: </i>2026 May 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8308647 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-9966 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203929078%22">03929078 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Clin Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13046-026-03729-z
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        Text: English
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      – TitleFull: Exosomal NEAT1 from tumor stem cells induces SIRPA+ macrophages to enhance immune evasion and glioblastoma progression via upregulating the HSP90B1/STAT3 axis.
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            – D: 11
              M: 05
              Text: 2026 May 11
              Type: published
              Y: 2026
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