Clinical impact of potential drug-drug interactions between midostaurin and posaconazole in FLT3-mutated AML.

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Title: Clinical impact of potential drug-drug interactions between midostaurin and posaconazole in FLT3-mutated AML.
Authors: Joisten CS; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Mellinghoff SC; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Seidel D; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Müller C; TDM Laboratory, Center for Laboratory Diagnostics, University Hospital of Cologne, Cologne, Germany., Müller-Ohrem C; TDM Laboratory, Center for Laboratory Diagnostics, University Hospital of Cologne, Cologne, Germany., Kreuzer K-A; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Frenzel LP; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Simon F; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Hallek M; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Koehler P; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Department I of Internal Medicine, Division of Clinical Immunology, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Cornely OA; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Clinical Trials Center Cologne (ZKS Köln), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Stemler J; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Jun 03; Vol. 70 (6), pp. e0195125. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1098-6596
DOI:10.1128/aac.01951-25