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Clinical impact of potential drug-drug interactions between midostaurin and posaconazole in FLT3-mutated AML.

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Title: Clinical impact of potential drug-drug interactions between midostaurin and posaconazole in FLT3-mutated AML.
Authors: Joisten CS; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Mellinghoff SC; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Seidel D; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Müller C; TDM Laboratory, Center for Laboratory Diagnostics, University Hospital of Cologne, Cologne, Germany., Müller-Ohrem C; TDM Laboratory, Center for Laboratory Diagnostics, University Hospital of Cologne, Cologne, Germany., Kreuzer K-A; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Frenzel LP; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Simon F; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Hallek M; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Koehler P; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Department I of Internal Medicine, Division of Clinical Immunology, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany., Cornely OA; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Clinical Trials Center Cologne (ZKS Köln), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Stemler J; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Jun 03; Vol. 70 (6), pp. e0195125. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
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  Data: Clinical impact of potential drug-drug interactions between midostaurin and posaconazole in FLT3-mutated AML.
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  Data: <searchLink fieldCode="AU" term="%22Joisten+CS%22">Joisten CS</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Mellinghoff+SC%22">Mellinghoff SC</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Seidel+D%22">Seidel D</searchLink>; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+C%22">Müller C</searchLink>; TDM Laboratory, Center for Laboratory Diagnostics, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Ohrem+C%22">Müller-Ohrem C</searchLink>; TDM Laboratory, Center for Laboratory Diagnostics, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kreuzer+K-A%22">Kreuzer K-A</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Frenzel+LP%22">Frenzel LP</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+F%22">Simon F</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hallek+M%22">Hallek M</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Koehler+P%22">Koehler P</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Department I of Internal Medicine, Division of Clinical Immunology, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Cornely+OA%22">Cornely OA</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Clinical Trials Center Cologne (ZKS Köln), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stemler+J%22">Stemler J</searchLink>; Department I of Internal Medicine, Center for Integrated Oncology (CIO), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2026 Jun 03; Vol. 70 (6), pp. e0195125. <i>Date of Electronic Publication: </i>2026 May 12.
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