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Associations between CRP-related DNA methylation, stress exposure, and depression severity in a longitudinal clinical cohort.

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Title: Associations between CRP-related DNA methylation, stress exposure, and depression severity in a longitudinal clinical cohort.
Authors: Usemann PL; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany. Electronic address: Paula.Usemann@uni-marburg.de., David FS; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Sagcob L; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany., Hammes VB; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Stein F; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Thomas-Odenthal F; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Teutenberg L; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Flinkenflügel K; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hubbert J; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Jurischka C; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Krieger J; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Leehr EJ; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Institute for Translational Neuroscience, University of Münster, Münster, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Repple J; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany., Opel N; Department of Psychiatry and Psychotherapy, University Hospital Jena, Jena, Germany; German Center for Mental Health (DZPG), Halle-Jena-Magdeburg, Halle, Germany., Melzer N; Department of Neurology, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Jamalabadi H; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Jansen A; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Straube B; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany., Nenadić I; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Bielefeld University, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Department of Psychiatry, Germany., Kircher T; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany., Alexander N; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany. Electronic address: Nina.Alexander@uni-marburg.de.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 May 12; Vol. 137, pp. 106807. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
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  Data: Associations between CRP-related DNA methylation, stress exposure, and depression severity in a longitudinal clinical cohort.
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  Data: <searchLink fieldCode="AU" term="%22Usemann+PL%22">Usemann PL</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany. Electronic address: Paula.Usemann@uni-marburg.de.<br /><searchLink fieldCode="AU" term="%22David+FS%22">David FS</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Sagcob+L%22">Sagcob L</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hammes+VB%22">Hammes VB</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Stein+F%22">Stein F</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas-Odenthal+F%22">Thomas-Odenthal F</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Teutenberg+L%22">Teutenberg L</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Flinkenflügel+K%22">Flinkenflügel K</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hubbert+J%22">Hubbert J</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Jurischka+C%22">Jurischka C</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Krieger+J%22">Krieger J</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Leehr+EJ%22">Leehr EJ</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Meinert+S%22">Meinert S</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Institute for Translational Neuroscience, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hahn+T%22">Hahn T</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Repple+J%22">Repple J</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Opel+N%22">Opel N</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital Jena, Jena, Germany; German Center for Mental Health (DZPG), Halle-Jena-Magdeburg, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Melzer+N%22">Melzer N</searchLink>; Department of Neurology, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Jamalabadi+H%22">Jamalabadi H</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jansen+A%22">Jansen A</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Straube+B%22">Straube B</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nöthen+MM%22">Nöthen MM</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Forstner+AJ%22">Forstner AJ</searchLink>; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Nenadić+I%22">Nenadić I</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dannlowski+U%22">Dannlowski U</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany; Bielefeld University, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Department of Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Kircher+T%22">Kircher T</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Alexander+N%22">Alexander N</searchLink>; Philipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany. Electronic address: Nina.Alexander@uni-marburg.de.
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