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Functional connectivity density alterations in obsessive-compulsive disorder are associated with neurotransmitter and genetic profiles.

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Title: Functional connectivity density alterations in obsessive-compulsive disorder are associated with neurotransmitter and genetic profiles.
Authors: Chen K; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Liu Y; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Xiao Y; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Cao F; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Zhu S; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Pan W; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Weng W; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Hong Y; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Hua Q; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China.; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China., Wan K; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Ye J; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Li Z; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Xiang S; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Yu F; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China., Wang K; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China. kwang@ahmu.edu.cn.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China. kwang@ahmu.edu.cn.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China. kwang@ahmu.edu.cn.; Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. kwang@ahmu.edu.cn., Ji G; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China. 2015500024@ahmu.edu.cn.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China. 2015500024@ahmu.edu.cn.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China. 2015500024@ahmu.edu.cn., Zhu C; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China. 1995500038@ahmu.edu.cn.; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China. 1995500038@ahmu.edu.cn.; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China. 1995500038@ahmu.edu.cn.; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. 1995500038@ahmu.edu.cn.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 12; Vol. 16 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-026-04073-8