Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures.

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Title: Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures.
Authors: Ke W; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China., Lyu S; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China., Jin M; State Key Laboratory of Neuroscience, Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Jiao S; AI for Science Interdisciplinary Research Center, School of Computer Science, Northwestern Polytechnical University, Xi'an, China., Li L; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China., Zhang H; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China., Ling K; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China., Tian C; iHuman Institute, ShanghaiTech University, Shanghai, China., Song Y; Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, HFCNS Institute of Artificial Intelligence, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Chen L; Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, HFCNS Institute of Artificial Intelligence, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., He Q; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China., Xiao Y; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China., Deng S; Center for Medical Genetics, School of Life Sciences, MOE Key Laboratory of Rare Pediatric Diseases, Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, Changsha, China., Fan L; Lingang Laboratory, Shanghai, China., Mu H; MOE Key Laboratory of Brain-Inspired Intelligent Perception and Cognition, National Engineering Laboratory for Brain-Inspired Intelligence Technology and Application, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China., Yang H; Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, China., Xu HT; Lingang Laboratory, Shanghai, China., Wang H; MOE Key Laboratory of Brain-Inspired Intelligent Perception and Cognition, National Engineering Laboratory for Brain-Inspired Intelligence Technology and Application, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China., Tang AH; Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, HFCNS Institute of Artificial Intelligence, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Peng J; AI for Science Interdisciplinary Research Center, School of Computer Science, Northwestern Polytechnical University, Xi'an, China. jiajiepeng@nwpu.edu.cn., He J; State Key Laboratory of Neuroscience, Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. jiehe@ion.ac.cn., Guo H; Department of Neurosurgery, Shanghai Deji Hospital-The 9th Clinical College, Qingdao University, Shanghai, China. guohui@shneuro.org., Shu Y; Department of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China. yousheng@fudan.edu.cn.
Source: Nature communications [Nat Commun] 2026 May 12; Vol. 17 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72935-2