A CD4+ T cell-fibroblast crosstalk exacerbates autoimmunity in a mouse model of primary Sjögren disease.

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Title: A CD4+ T cell-fibroblast crosstalk exacerbates autoimmunity in a mouse model of primary Sjögren disease.
Authors: Otsuka K; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan.; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Kondo H; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan., Tsukumo SI; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan., Kurotaki D; Laboratory of Chromatin Structure in Immunity, Chronic Inflammation Research Initiative, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima, Japan.; Laboratory of Chromatin Organization in Immune Cell Development, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan., Yasunaga KI; Liaison Laboratory Research Promotion Center, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan., Ushio A; Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Nagao R; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Aota K; Department of Oral and Maxillofacial Disease Control, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Kitamura Y; Department of Otolaryngology, Graduate School of Medicine, Tokushima University, Tokushima, Japan., Tsunematsu T; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Yagita H; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan., Ishimaru N; Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Morimoto J; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan., Yasutomo K; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp.; Laboratory of Immunology, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp.
Source: Nature communications [Nat Commun] 2026 May 12; Vol. 17 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72975-8