A CD4+ T cell-fibroblast crosstalk exacerbates autoimmunity in a mouse model of primary Sjögren disease.
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| Title: | A CD4+ T cell-fibroblast crosstalk exacerbates autoimmunity in a mouse model of primary Sjögren disease. |
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| Authors: | Otsuka K; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan.; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Kondo H; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan., Tsukumo SI; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan., Kurotaki D; Laboratory of Chromatin Structure in Immunity, Chronic Inflammation Research Initiative, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima, Japan.; Laboratory of Chromatin Organization in Immune Cell Development, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan., Yasunaga KI; Liaison Laboratory Research Promotion Center, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan., Ushio A; Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Nagao R; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Aota K; Department of Oral and Maxillofacial Disease Control, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Kitamura Y; Department of Otolaryngology, Graduate School of Medicine, Tokushima University, Tokushima, Japan., Tsunematsu T; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan., Yagita H; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan., Ishimaru N; Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Morimoto J; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan., Yasutomo K; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp.; Laboratory of Immunology, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp. |
| Source: | Nature communications [Nat Commun] 2026 May 12; Vol. 17 (1). Date of Electronic Publication: 2026 May 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42120415 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A CD4<superscript>+</superscript> T cell-fibroblast crosstalk exacerbates autoimmunity in a mouse model of primary Sjögren disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Otsuka+K%22">Otsuka K</searchLink>; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan.; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Kondo+H%22">Kondo H</searchLink>; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Tsukumo+SI%22">Tsukumo SI</searchLink>; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Kurotaki+D%22">Kurotaki D</searchLink>; Laboratory of Chromatin Structure in Immunity, Chronic Inflammation Research Initiative, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima, Japan.; Laboratory of Chromatin Organization in Immune Cell Development, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yasunaga+KI%22">Yasunaga KI</searchLink>; Liaison Laboratory Research Promotion Center, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ushio+A%22">Ushio A</searchLink>; Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nagao+R%22">Nagao R</searchLink>; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Aota+K%22">Aota K</searchLink>; Department of Oral and Maxillofacial Disease Control, Graduate School of Dentistry, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Kitamura+Y%22">Kitamura Y</searchLink>; Department of Otolaryngology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Tsunematsu+T%22">Tsunematsu T</searchLink>; Department of Oral Pathology, Graduate School of Dentistry, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Yagita+H%22">Yagita H</searchLink>; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ishimaru+N%22">Ishimaru N</searchLink>; Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Morimoto+J%22">Morimoto J</searchLink>; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Yasutomo+K%22">Yasutomo K</searchLink>; Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp.; Department of Interdisciplinary Research for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp.; Laboratory of Immunology, Institute of Photonics and Human Health Frontier, Tokushima University, Tokushima, Japan. yasutomo@tokushima-u.ac.jp. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 12; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42120415 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-72975-8 Languages: – Code: eng Text: English Titles: – TitleFull: A CD4+ T cell-fibroblast crosstalk exacerbates autoimmunity in a mouse model of primary Sjögren disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Otsuka K – PersonEntity: Name: NameFull: Kondo H – PersonEntity: Name: NameFull: Tsukumo SI – PersonEntity: Name: NameFull: Kurotaki D – PersonEntity: Name: NameFull: Yasunaga KI – PersonEntity: Name: NameFull: Ushio A – PersonEntity: Name: NameFull: Nagao R – PersonEntity: Name: NameFull: Aota K – PersonEntity: Name: NameFull: Kitamura Y – PersonEntity: Name: NameFull: Tsunematsu T – PersonEntity: Name: NameFull: Yagita H – PersonEntity: Name: NameFull: Ishimaru N – PersonEntity: Name: NameFull: Morimoto J – PersonEntity: Name: NameFull: Yasutomo K IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 05 Text: 2026 May 12 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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