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An RHD gene variant, common in southern Chinese Han, involves a short 688 bp deletion and a long 21.8 kb insertion in the RHD exon 10 non-coding region, affecting the accuracy of red cell genotyping.

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Title: An RHD gene variant, common in southern Chinese Han, involves a short 688 bp deletion and a long 21.8 kb insertion in the RHD exon 10 non-coding region, affecting the accuracy of red cell genotyping.
Authors: Wen J; Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China.; The Key Medical Laboratory of Guangzhou, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China., He F; Department of Blood Transfusion, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Veldhuisen B; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Mo C; Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China.; The Key Medical Laboratory of Guangzhou, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China., Wei L; Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China.; The Key Medical Laboratory of Guangzhou, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China., Jia S; Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China.; The Key Medical Laboratory of Guangzhou, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China., van der Schoot CE; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Flegel WA; Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892-1184, USA. waf@nih.gov., Ji Y; Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China. jiyanli2013@163.com.; The Key Medical Laboratory of Guangzhou, No31, Luyuan Road, Yuexiu District, Guangzhou, 510095, China. jiyanli2013@163.com.
Source: Journal of translational medicine [J Transl Med] 2026 May 12; Vol. 24 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-08183-1