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Multiscale molecular modeling-directed ROS-responsive nanotherapy for dual-axis regulation of fibrotic and inflammatory signaling in alport nephropathy.

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Title: Multiscale molecular modeling-directed ROS-responsive nanotherapy for dual-axis regulation of fibrotic and inflammatory signaling in alport nephropathy.
Authors: Choi HS; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea., Sundaram A; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea.; DR Cure Inc., Hwasun, 58128, Republic of Korea., Vasukutty A; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea., Mathew AP; Department of Chemical and Biological Engineering, Iowa State University, Iowa, USA.; Nanovaccine Institute, Iowa State University, Iowa, USA., Sathiyamoorthy P; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea., Kim IJ; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea., Suh SH; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea., Kim CS; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea., Ma SK; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea., Kim SW; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea., Park IK; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea. pik96@jnu.ac.kr.; DR Cure Inc., Hwasun, 58128, Republic of Korea. pik96@jnu.ac.kr., Bae EH; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea. baedak76@gmail.com.; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea. baedak76@gmail.com.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 May 12; Vol. 24 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiscale molecular modeling-directed ROS-responsive nanotherapy for dual-axis regulation of fibrotic and inflammatory signaling in alport nephropathy.
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  Data: <searchLink fieldCode="AU" term="%22Choi+HS%22">Choi HS</searchLink>; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sundaram+A%22">Sundaram A</searchLink>; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea.; DR Cure Inc., Hwasun, 58128, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Vasukutty+A%22">Vasukutty A</searchLink>; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Mathew+AP%22">Mathew AP</searchLink>; Department of Chemical and Biological Engineering, Iowa State University, Iowa, USA.; Nanovaccine Institute, Iowa State University, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Sathiyamoorthy+P%22">Sathiyamoorthy P</searchLink>; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+IJ%22">Kim IJ</searchLink>; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Suh+SH%22">Suh SH</searchLink>; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+CS%22">Kim CS</searchLink>; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ma+SK%22">Ma SK</searchLink>; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SW%22">Kim SW</searchLink>; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+IK%22">Park IK</searchLink>; Department of Biomedical Sciences, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Chonnam National University, 322 Seoyang-ro, Hwasun-gun, Hwasun, 58128, Jeollanam-do, Republic of Korea. pik96@jnu.ac.kr.; DR Cure Inc., Hwasun, 58128, Republic of Korea. pik96@jnu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Bae+EH%22">Bae EH</searchLink>; Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea. baedak76@gmail.com.; Department of Internal Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea. baedak76@gmail.com.
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        Value: 10.1186/s12951-026-04451-w
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      – TitleFull: Multiscale molecular modeling-directed ROS-responsive nanotherapy for dual-axis regulation of fibrotic and inflammatory signaling in alport nephropathy.
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              Text: 2026 May 12
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