Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver-bone model.

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Title: Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver-bone model.
Authors: Hammour MM; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Herzberger L; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.; Boehringer Ingelheim Pharma GmbH & Co. KG, NCE, Biberach an der Riss, Germany., Xin Y; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Chen G; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Tombaz M; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Ehnert S; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Springer F; Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Hoppe- Seyler-Str. 3, 72076, Tübingen, Germany.; Department of Radiology, BG-Klinik Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, Thoracic and Vascular Surgery, Clinic for Visceral, Leipzig University Medical Center, 04103, Transplant, Leipzig, Germany., Vosough M; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.; Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Hengstler JG; Leibniz Research Center for Working Environment and Human Factors (IfADo), 44139, Dortmund, Germany., Müller-Vieira U; Boehringer Ingelheim Pharma GmbH & Co. KG, NCE, Biberach an der Riss, Germany., Nüssler AK; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Aspera-Werz RH; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany. Romina.Aspera-Werz@med.uni-tuebingen.de.
Source: Archives of toxicology [Arch Toxicol] 2026 May 13. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0738
DOI:10.1007/s00204-026-04431-x