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Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver-bone model.

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Title: Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver-bone model.
Authors: Hammour MM; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Herzberger L; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.; Boehringer Ingelheim Pharma GmbH & Co. KG, NCE, Biberach an der Riss, Germany., Xin Y; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Chen G; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Tombaz M; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Ehnert S; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Springer F; Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Hoppe- Seyler-Str. 3, 72076, Tübingen, Germany.; Department of Radiology, BG-Klinik Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, Thoracic and Vascular Surgery, Clinic for Visceral, Leipzig University Medical Center, 04103, Transplant, Leipzig, Germany., Vosough M; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.; Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden., Hengstler JG; Leibniz Research Center for Working Environment and Human Factors (IfADo), 44139, Dortmund, Germany., Müller-Vieira U; Boehringer Ingelheim Pharma GmbH & Co. KG, NCE, Biberach an der Riss, Germany., Nüssler AK; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany., Aspera-Werz RH; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany. Romina.Aspera-Werz@med.uni-tuebingen.de.
Source: Archives of toxicology [Arch Toxicol] 2026 May 13. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hammour+MM%22">Hammour MM</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Herzberger+L%22">Herzberger L</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.; Boehringer Ingelheim Pharma GmbH & Co. KG, NCE, Biberach an der Riss, Germany.<br /><searchLink fieldCode="AU" term="%22Xin+Y%22">Xin Y</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Tombaz+M%22">Tombaz M</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ehnert+S%22">Ehnert S</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Springer+F%22">Springer F</searchLink>; Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Hoppe- Seyler-Str. 3, 72076, Tübingen, Germany.; Department of Radiology, BG-Klinik Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Damm+G%22">Damm G</searchLink>; Department of Hepatobiliary Surgery and Visceral Transplantation, Thoracic and Vascular Surgery, Clinic for Visceral, Leipzig University Medical Center, 04103, Transplant, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Vosough+M%22">Vosough M</searchLink>; Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.; Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hengstler+JG%22">Hengstler JG</searchLink>; Leibniz Research Center for Working Environment and Human Factors (IfADo), 44139, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Vieira+U%22">Müller-Vieira U</searchLink>; Boehringer Ingelheim Pharma GmbH & Co. KG, NCE, Biberach an der Riss, Germany.<br /><searchLink fieldCode="AU" term="%22Nüssler+AK%22">Nüssler AK</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Aspera-Werz+RH%22">Aspera-Werz RH</searchLink>; Department of Traumatology, Siegfried Weller Institute, BG Clinic Tübingen, Eberhard Karls University, 72076, Tübingen, Germany. Romina.Aspera-Werz@med.uni-tuebingen.de.
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