ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E.

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Bibliographic Details
Title: ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E.
Authors: Yang X; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Qiao X; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Schmidt S; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Eklund EA; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden.; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden., Ebner-Walter C; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Ivarsson E; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Crespo MA; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Kersemakers N; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Dzanan JJ; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden., Thorisson B; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden., Lundgren C; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Lim HC; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Shkoukani S; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Tüksammel E; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Xu X; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Sayin VI; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden.; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden., Martín-Fontecha M; Organic Chemistry Department, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid 28040, Spain., Ortega-Gutiérrez S; Organic Chemistry Department, Faculty of Chemical Sciences, Universidad Complutense de Madrid, Madrid 28040, Spain., Dalin M; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-416 85, Sweden., Bergo MO; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2601795123. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2601795123