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ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E.

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Title: ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E.
Authors: Yang X; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Qiao X; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Schmidt S; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Eklund EA; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden.; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden., Ebner-Walter C; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Ivarsson E; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Crespo MA; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Kersemakers N; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Dzanan JJ; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden., Thorisson B; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden., Lundgren C; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Lim HC; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Shkoukani S; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden., Tüksammel E; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Xu X; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden., Sayin VI; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden.; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden., Martín-Fontecha M; Organic Chemistry Department, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid 28040, Spain., Ortega-Gutiérrez S; Organic Chemistry Department, Faculty of Chemical Sciences, Universidad Complutense de Madrid, Madrid 28040, Spain., Dalin M; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-416 85, Sweden., Bergo MO; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2601795123. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: ICMT supports BRAF<superscript>V600E</superscript>-driven tumor growth by membrane targeting of the CAAX protein INPP5E.
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  Data: <searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Qiao+X%22">Qiao X</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Schmidt+S%22">Schmidt S</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Eklund+EA%22">Eklund EA</searchLink>; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden.; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Ebner-Walter+C%22">Ebner-Walter C</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Ivarsson+E%22">Ivarsson E</searchLink>; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Crespo+MA%22">Crespo MA</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Kersemakers+N%22">Kersemakers N</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Dzanan+JJ%22">Dzanan JJ</searchLink>; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden.<br /><searchLink fieldCode="AU" term="%22Thorisson+B%22">Thorisson B</searchLink>; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Lundgren+C%22">Lundgren C</searchLink>; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Lim+HC%22">Lim HC</searchLink>; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Shkoukani+S%22">Shkoukani S</searchLink>; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Tüksammel+E%22">Tüksammel E</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Sayin+VI%22">Sayin VI</searchLink>; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Sweden.; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.<br /><searchLink fieldCode="AU" term="%22Martín-Fontecha+M%22">Martín-Fontecha M</searchLink>; Organic Chemistry Department, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid 28040, Spain.<br /><searchLink fieldCode="AU" term="%22Ortega-Gutiérrez+S%22">Ortega-Gutiérrez S</searchLink>; Organic Chemistry Department, Faculty of Chemical Sciences, Universidad Complutense de Madrid, Madrid 28040, Spain.<br /><searchLink fieldCode="AU" term="%22Dalin+M%22">Dalin M</searchLink>; Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Sweden.; Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-416 85, Sweden.<br /><searchLink fieldCode="AU" term="%22Bergo+MO%22">Bergo MO</searchLink>; Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Sweden.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 May 19; Vol. 123 (20), pp. e2601795123. <i>Date of Electronic Publication: </i>2026 May 13.
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