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Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts.

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Title: Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts.
Authors: Merkt W; Division of Rheumatology, Department of Hematology, Oncology and Rheumatology, Internal Medicine V, Medical Faculty, Heidelberg University; 69120 Heidelberg, Germany.; Hiller Research Center, Department of Rheumatology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL); 69120 Heidelberg, Germany.; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA 02114, USA.; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Rodon L; Division of Rheumatology, Department of Hematology, Oncology and Rheumatology, Internal Medicine V, Medical Faculty, Heidelberg University; 69120 Heidelberg, Germany., Deicher FS; Division of Rheumatology, Department of Hematology, Oncology and Rheumatology, Internal Medicine V, Medical Faculty, Heidelberg University; 69120 Heidelberg, Germany., Freitag M; Division of Rheumatology, Department of Hematology, Oncology and Rheumatology, Internal Medicine V, Medical Faculty, Heidelberg University; 69120 Heidelberg, Germany., Claus M; Leibniz Research Center for Working Environment and Human Factors at TU Dortmund (IfADo), 44139 Dortmund, Germany., Lister R; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA 02114, USA., Han H; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA 02114, USA., Zhou Y; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA 02114, USA., Horne A; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 10115 Berlin, Germany., Stütz A; Hiller Research Center, Department of Rheumatology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany., Li YN; Hiller Research Center, Department of Rheumatology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany., Kreuter M; Mainz Center for Pulmonary Medicine, Department of Pneumology, Mainz University Medical Center and Department of Pulmonary, Critical Care & Sleep Medicine, Marienhaus Clinic Mainz, 55131 Mainz, Germany., Kahn N; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL); 69120 Heidelberg, Germany.; Department of Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University Hospital Heidelberg, 69126 Heidelberg, Germany., Schneider MA; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL); 69120 Heidelberg, Germany.; Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, 69126 Heidelberg, Germany., Egea-Zorrilla A; Institute for Lung Health (ILH), Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392, Giessen, Germany.; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany., Blasco-Iturri Z; Institute for Lung Health (ILH), Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392, Giessen, Germany.; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany., Nikulina N; Institute for Lung Health (ILH), Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392, Giessen, Germany.; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany.; Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany., Turkowski K; Institute for Lung Health (ILH), Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392, Giessen, Germany.; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany.; Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany., Ruppert C; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany.; European IPF Registry/Biobank, 35392 Giessen, Germany.; Center for Interstitial and Rare Lung Diseases, Department of Pulmonary and Critical Care Medicine, Justus Liebig-University, member of the German Center for Lung Research (DZL) 35392 Giessen, Germany., Guenther A; Institute for Lung Health (ILH), Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392, Giessen, Germany.; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany.; European IPF Registry/Biobank, 35392 Giessen, Germany.; Center for Interstitial and Rare Lung Diseases, Department of Pulmonary and Critical Care Medicine, Justus Liebig-University, member of the German Center for Lung Research (DZL) 35392 Giessen, Germany., Rizzo R; Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy., Rizzo S; Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy., Ferraresi M; Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy., Hübschmann D; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Innovation and Service Unit for Bioinformatics and Precision Medicine (BPM), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Pattern Recognition and Digital Medicine Group (PRDM), Heidelberg Institute for Stem cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Haas S; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 10115 Berlin, Germany., Blank N; Division of Rheumatology, Department of Hematology, Oncology and Rheumatology, Internal Medicine V, Medical Faculty, Heidelberg University; 69120 Heidelberg, Germany., Watzl C; Leibniz Research Center for Working Environment and Human Factors at TU Dortmund (IfADo), 44139 Dortmund, Germany., Tykocinski LO; Division of Rheumatology, Department of Hematology, Oncology and Rheumatology, Internal Medicine V, Medical Faculty, Heidelberg University; 69120 Heidelberg, Germany., Lorenz HM; Division of Rheumatology, Department of Hematology, Oncology and Rheumatology, Internal Medicine V, Medical Faculty, Heidelberg University; 69120 Heidelberg, Germany., Savai R; Institute for Lung Health (ILH), Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392, Giessen, Germany.; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany.; Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany., Pardo-Saganta A; Institute for Lung Health (ILH), Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392, Giessen, Germany.; Department of Internal Medicine, Member of the DZL, Member of CPI, Justus Liebig University, 35392, Giessen, Germany., Lagares D; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA 02114, USA.; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, Boston, MA 02114, USA.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Source: Science translational medicine [Sci Transl Med] 2026 May 13; Vol. 18 (849), pp. eadq5442. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.adq5442