Therapeutic potential of nicorandil vs nebivolol in attenuating PKC/P38MAPK signaling via PPARγ/KLOTHO/CREB pathway signaling: molecular docking and experimental validation in rat model of unilateral ureteric obstruction.

Saved in:
Bibliographic Details
Title: Therapeutic potential of nicorandil vs nebivolol in attenuating PKC/P38MAPK signaling via PPARγ/KLOTHO/CREB pathway signaling: molecular docking and experimental validation in rat model of unilateral ureteric obstruction.
Authors: Khalifa AK; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Nahda University, Beni Suef, 62521, Egypt. Electronic address: amirakaramkhalifa@cu.edu.eg., Galal AM; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt. Electronic address: amrmaher@kasralainy.edu.eg., Saber S; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. Electronic address: sameh.saber@deltauniv.edu.eg., El-Sayed AF; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt. Electronic address: ahmedfikry.nrc@gmail.com., Alsibaee AM; Department of pharmacognosy and pharmaceutical chemistry, College of pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Asibaee@taibahu.edu.sa., Saeedi T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Tahsaedi@taibahu.edu.sa., Alsubhi S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: smssubhi@taibahu.edu.sa., Miski SF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Smiski@taibahu.edu.sa., Aboulhoda BE; Department of Medical Anatomy and Embryology, Faculty of Medicine, Cairo University, El- Manial, Cairo, Egypt. Electronic address: basma.emad@kasralainy.edu.eg., Mohamed EEE; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, El- Manial, Cairo, Egypt. Electronic address: eman.emadeldin@kasralainy.edu.eg., Wanas H; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Hanaa.wanas@karalainy.edu.eg.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jun 15; Vol. 1027, pp. 178962. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0712
DOI:10.1016/j.ejphar.2026.178962