Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.

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Title: Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.
Authors: Batani V; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Cavazzana I; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Orlandi M; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., De Angelis R; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Campochiaro C; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy., De Lorenzis E; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Natalello G; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Verardi L; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bajocchi G; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy., Bellando-Randone S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology Scleroderma Unit, AOUC, University of Florence, Florence, Italy., Zanframundo G; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy., Foti R; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy., Cacciapaglia F; Rheumatology Unit, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy.; Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima & Rheumatology Service 'Miulli' General Hospital Acquaviva delle Fonti, Bari, Italy., Cuomo G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Ariani A; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy., Rosato E; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Lepri G; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Girelli F; Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy., Riccieri V; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Zanatta E; Department of Rheumatology, University of Padua, Padua, Italy., Ingegnoli F; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Dipartimento di Eccellenza 2023-2027, Università degli Studi di Milano, Milan, Italy., De Santis M; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Murdaca G; Research Hospital San Martino, University of Genoa, Genoa, Italy., Abignano G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Giorgio P; Azienda Ospedaliera S Croce e Carle, Cuneo, Italy., Della Rossa A; Department of Rheumatology, University of Pisa, Pisa, Italy., Caminiti M; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Iuliano AM; Rheumatology Unit, San Camillo-Forlanini Hospital, Roma, Italy., Beretta L; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy., Bagnato G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Lubrano E; Department of Rheumatology, University of Molise, Campobasso, Italy., De Andres I; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione 'Garibaldi', Catania, Italy., Idolazzi L; Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy., Bruni C; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Fornaro M; Rheumatology Unit, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy., Saracco M; Rheumatology Unit, Mauriziano-Umberto I Hospital, Torino, Italy., Agnes C; San Lorenzo Hospital, Carmagnola, Italy., Cipolletta E; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Lumetti F; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Spinella A; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., De Pinto M; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Magnani L; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Codullo V; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Visalli E; Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima & Rheumatology Service 'Miulli' General Hospital Acquaviva delle Fonti, Bari, Italy., Iandoli C; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Gigante A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Pellegrino G; IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, University of Milan, Milan, Italy., Pigatto E; Medicine Unit, Azienda Pedemontana 7, Ospedale San Bassiano, Bassano del Grappa, Italy., Lazzaroni MG; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Franceschini F; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Motta F; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Tonutti A; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Mennillo G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Di Battista M; Department of Rheumatology, University of Pisa, Pisa, Italy., Mariano GP; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Furini F; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Vultaggio L; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Parisi S; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Peroni CL; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Bianchi G; Rheumatology Unit, Department of Musculoskeletal Sciences, Local Health Trust La Colletta Hospital, Genova, Italy., Fusaro E; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Sebastiani GD; Rheumatology Unit, San Camillo-Forlanini Hospital, Roma, Italy., Govoni M; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., D'Angelo S; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Cozzi F; Department of Medicine, Villa Salus Hospital, Venice, Italy., Guiducci S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology Scleroderma Unit, AOUC, University of Florence, Florence, Italy., Doria A; Department of Rheumatology, University of Padua, Padua, Italy., Salvarani C; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy., Iannone F; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy., D'Agostino MA; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bosello SL; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Dagna L; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy., Giuggioli D; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Ferri C; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Matucci Cerinic M; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy., De Luca G; Vita-Salute San Raffaele University, Milan, Italy deluca.giacomo@hsr.it.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.
Corporate Authors: On the behalf of SPRING collaborators
Source: RMD open [RMD Open] 2026 May 13; Vol. 12 (2). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2056-5933
DOI:10.1136/rmdopen-2025-006495