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Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.

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Title: Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.
Authors: Batani V; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Cavazzana I; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Orlandi M; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., De Angelis R; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Campochiaro C; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy., De Lorenzis E; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Natalello G; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Verardi L; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bajocchi G; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy., Bellando-Randone S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology Scleroderma Unit, AOUC, University of Florence, Florence, Italy., Zanframundo G; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy., Foti R; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy., Cacciapaglia F; Rheumatology Unit, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy.; Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima & Rheumatology Service 'Miulli' General Hospital Acquaviva delle Fonti, Bari, Italy., Cuomo G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Ariani A; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy., Rosato E; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Lepri G; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Girelli F; Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy., Riccieri V; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Zanatta E; Department of Rheumatology, University of Padua, Padua, Italy., Ingegnoli F; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Dipartimento di Eccellenza 2023-2027, Università degli Studi di Milano, Milan, Italy., De Santis M; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Murdaca G; Research Hospital San Martino, University of Genoa, Genoa, Italy., Abignano G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Giorgio P; Azienda Ospedaliera S Croce e Carle, Cuneo, Italy., Della Rossa A; Department of Rheumatology, University of Pisa, Pisa, Italy., Caminiti M; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Iuliano AM; Rheumatology Unit, San Camillo-Forlanini Hospital, Roma, Italy., Beretta L; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy., Bagnato G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Lubrano E; Department of Rheumatology, University of Molise, Campobasso, Italy., De Andres I; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione 'Garibaldi', Catania, Italy., Idolazzi L; Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy., Bruni C; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Fornaro M; Rheumatology Unit, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy., Saracco M; Rheumatology Unit, Mauriziano-Umberto I Hospital, Torino, Italy., Agnes C; San Lorenzo Hospital, Carmagnola, Italy., Cipolletta E; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Lumetti F; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Spinella A; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., De Pinto M; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Magnani L; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Codullo V; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Visalli E; Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima & Rheumatology Service 'Miulli' General Hospital Acquaviva delle Fonti, Bari, Italy., Iandoli C; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Gigante A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Pellegrino G; IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, University of Milan, Milan, Italy., Pigatto E; Medicine Unit, Azienda Pedemontana 7, Ospedale San Bassiano, Bassano del Grappa, Italy., Lazzaroni MG; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Franceschini F; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Motta F; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Tonutti A; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Mennillo G; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Di Battista M; Department of Rheumatology, University of Pisa, Pisa, Italy., Mariano GP; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Furini F; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Vultaggio L; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., Parisi S; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Peroni CL; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Bianchi G; Rheumatology Unit, Department of Musculoskeletal Sciences, Local Health Trust La Colletta Hospital, Genova, Italy., Fusaro E; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy., Sebastiani GD; Rheumatology Unit, San Camillo-Forlanini Hospital, Roma, Italy., Govoni M; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy., D'Angelo S; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy., Cozzi F; Department of Medicine, Villa Salus Hospital, Venice, Italy., Guiducci S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology Scleroderma Unit, AOUC, University of Florence, Florence, Italy., Doria A; Department of Rheumatology, University of Padua, Padua, Italy., Salvarani C; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy., Iannone F; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy., D'Agostino MA; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bosello SL; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Dagna L; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy., Giuggioli D; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Ferri C; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy., Matucci Cerinic M; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy., De Luca G; Vita-Salute San Raffaele University, Milan, Italy deluca.giacomo@hsr.it.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.
Corporate Authors: On the behalf of SPRING collaborators
Source: RMD open [RMD Open] 2026 May 13; Vol. 12 (2). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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AccessLevel: 2
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Batani+V%22">Batani V</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Cavazzana+I%22">Cavazzana I</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Orlandi+M%22">Orlandi M</searchLink>; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22De+Angelis+R%22">De Angelis R</searchLink>; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Campochiaro+C%22">Campochiaro C</searchLink>; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Lorenzis+E%22">De Lorenzis E</searchLink>; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Natalello+G%22">Natalello G</searchLink>; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Verardi+L%22">Verardi L</searchLink>; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bajocchi+G%22">Bajocchi G</searchLink>; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Bellando-Randone+S%22">Bellando-Randone S</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology Scleroderma Unit, AOUC, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Zanframundo+G%22">Zanframundo G</searchLink>; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Foti+R%22">Foti R</searchLink>; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Cacciapaglia+F%22">Cacciapaglia F</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy.; Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima & Rheumatology Service 'Miulli' General Hospital Acquaviva delle Fonti, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Cuomo+G%22">Cuomo G</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Ariani+A%22">Ariani A</searchLink>; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Rosato+E%22">Rosato E</searchLink>; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lepri+G%22">Lepri G</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Girelli+F%22">Girelli F</searchLink>; Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy.<br /><searchLink fieldCode="AU" term="%22Riccieri+V%22">Riccieri V</searchLink>; Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zanatta+E%22">Zanatta E</searchLink>; Department of Rheumatology, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Ingegnoli+F%22">Ingegnoli F</searchLink>; Clinical Rheumatology Unit, ASST Gaetano Pini-CTO, Department of Clinical Sciences & Community Health, Dipartimento di Eccellenza 2023-2027, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Santis+M%22">De Santis M</searchLink>; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy.<br /><searchLink fieldCode="AU" term="%22Murdaca+G%22">Murdaca G</searchLink>; Research Hospital San Martino, University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Abignano+G%22">Abignano G</searchLink>; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgio+P%22">Giorgio P</searchLink>; Azienda Ospedaliera S Croce e Carle, Cuneo, Italy.<br /><searchLink fieldCode="AU" term="%22Della+Rossa+A%22">Della Rossa A</searchLink>; Department of Rheumatology, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Caminiti+M%22">Caminiti M</searchLink>; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Iuliano+AM%22">Iuliano AM</searchLink>; Rheumatology Unit, San Camillo-Forlanini Hospital, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Beretta+L%22">Beretta L</searchLink>; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bagnato+G%22">Bagnato G</searchLink>; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Lubrano+E%22">Lubrano E</searchLink>; Department of Rheumatology, University of Molise, Campobasso, Italy.<br /><searchLink fieldCode="AU" term="%22De+Andres+I%22">De Andres I</searchLink>; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione 'Garibaldi', Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Idolazzi+L%22">Idolazzi L</searchLink>; Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Bruni+C%22">Bruni C</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Fornaro+M%22">Fornaro M</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine and Jonic Area, University of Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Saracco+M%22">Saracco M</searchLink>; Rheumatology Unit, Mauriziano-Umberto I Hospital, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Agnes+C%22">Agnes C</searchLink>; San Lorenzo Hospital, Carmagnola, Italy.<br /><searchLink fieldCode="AU" term="%22Cipolletta+E%22">Cipolletta E</searchLink>; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Lumetti+F%22">Lumetti F</searchLink>; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Spinella+A%22">Spinella A</searchLink>; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22De+Pinto+M%22">De Pinto M</searchLink>; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Magnani+L%22">Magnani L</searchLink>; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Codullo+V%22">Codullo V</searchLink>; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Visalli+E%22">Visalli E</searchLink>; Department of Medicine and Surgery, LUM University 'Giuseppe De Gennaro' Casamassima & Rheumatology Service 'Miulli' General Hospital Acquaviva delle Fonti, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Iandoli+C%22">Iandoli C</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Caserta, Italy.<br /><searchLink fieldCode="AU" term="%22Gigante+A%22">Gigante A</searchLink>; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pellegrino+G%22">Pellegrino G</searchLink>; IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pigatto+E%22">Pigatto E</searchLink>; Medicine Unit, Azienda Pedemontana 7, Ospedale San Bassiano, Bassano del Grappa, Italy.<br /><searchLink fieldCode="AU" term="%22Lazzaroni+MG%22">Lazzaroni MG</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Franceschini+F%22">Franceschini F</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Motta+F%22">Motta F</searchLink>; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy.<br /><searchLink fieldCode="AU" term="%22Tonutti+A%22">Tonutti A</searchLink>; Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy.<br /><searchLink fieldCode="AU" term="%22Mennillo+G%22">Mennillo G</searchLink>; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Battista+M%22">Di Battista M</searchLink>; Department of Rheumatology, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Mariano+GP%22">Mariano GP</searchLink>; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Furini+F%22">Furini F</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Vultaggio+L%22">Vultaggio L</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Parisi+S%22">Parisi S</searchLink>; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Peroni+CL%22">Peroni CL</searchLink>; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Bianchi+G%22">Bianchi G</searchLink>; Rheumatology Unit, Department of Musculoskeletal Sciences, Local Health Trust La Colletta Hospital, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Fusaro+E%22">Fusaro E</searchLink>; Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Sebastiani+GD%22">Sebastiani GD</searchLink>; Rheumatology Unit, San Camillo-Forlanini Hospital, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Govoni+M%22">Govoni M</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Azienda Ospedaliera-Universitaria S. Anna di Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22D'Angelo+S%22">D'Angelo S</searchLink>; Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Cozzi+F%22">Cozzi F</searchLink>; Department of Medicine, Villa Salus Hospital, Venice, Italy.<br /><searchLink fieldCode="AU" term="%22Guiducci+S%22">Guiducci S</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology Scleroderma Unit, AOUC, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Doria+A%22">Doria A</searchLink>; Department of Rheumatology, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Salvarani+C%22">Salvarani C</searchLink>; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and University of Modena and Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Iannone+F%22">Iannone F</searchLink>; Rheumatology Unit, A.O.U Policlinico S. Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22D'Agostino+MA%22">D'Agostino MA</searchLink>; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bosello+SL%22">Bosello SL</searchLink>; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Dagna+L%22">Dagna L</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Giuggioli+D%22">Giuggioli D</searchLink>; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Ferri+C%22">Ferri C</searchLink>; Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Matucci+Cerinic+M%22">Matucci Cerinic M</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+G%22">De Luca G</searchLink>; Vita-Salute San Raffaele University, Milan, Italy deluca.giacomo@hsr.it.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Inflammation, Fibrosis and Ageing Initiative (INFLAGE), IRCCS Ospedale San Raffaele, Milan, Italy.
– Name: AuthorCorporate
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  Data: <searchLink fieldCode="CA" term="%22On+the+behalf+of+SPRING+collaborators%22">On the behalf of SPRING collaborators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101662038%22">RMD open</searchLink> [RMD Open] 2026 May 13; Vol. 12 (2). <i>Date of Electronic Publication: </i>2026 May 13.
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  Data: Journal Article; Multicenter Study
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  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group%22">BMJ Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101662038 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2056-5933 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220565933%22">20565933 </searchLink><i>NLM ISO Abbreviation: </i>RMD Open <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42128529
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    Identifiers:
      – Type: doi
        Value: 10.1136/rmdopen-2025-006495
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Clinical and serological features of triple autoantibody-negative patients with systemic sclerosis: insights from the multicentric SPRING registry of the Italian Society for Rheumatology.
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          Dates:
            – D: 13
              M: 05
              Text: 2026 May 13
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2056-5933
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              Value: 12
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: RMD open
              Type: main
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