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Schizantherin B alleviates cisplatin-induced ototoxicity and does not interfere cisplatin-based chemotherapy in a breast cancer model.

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Title: Schizantherin B alleviates cisplatin-induced ototoxicity and does not interfere cisplatin-based chemotherapy in a breast cancer model.
Authors: Zhao Z; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.; Department of Otolaryngology, Yueyang Hospital of Integrative Chinese & Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China., Han L; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.; Department of Otorhinolaryngology, The Second Affiliated Hospital, University of South China, Hengyang, 421001, China., Xu Z; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.; Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, 230088, China., Nan B; Department of Otorhinolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China., Tang H; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China., Dong D; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China., Zen Z; Department of ENT of the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China., Gao Z; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China., Ye C; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China., Huang X; Department of Otorhinolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China. huang.xinsheng@zs-hospital.sh.cn., Zhang J; Department of Otolaryngology, Yueyang Hospital of Integrative Chinese & Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China. eternityz@sina.com., Li GL; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. genglin.li@fdeent.org.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China. genglin.li@fdeent.org.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China. genglin.li@fdeent.org., Shu Y; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.
Source: Archives of toxicology [Arch Toxicol] 2026 May 13. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Schizantherin B alleviates cisplatin-induced ototoxicity and does not interfere cisplatin-based chemotherapy in a breast cancer model.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.; Department of Otolaryngology, Yueyang Hospital of Integrative Chinese & Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.<br /><searchLink fieldCode="AU" term="%22Han+L%22">Han L</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.; Department of Otorhinolaryngology, The Second Affiliated Hospital, University of South China, Hengyang, 421001, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.; Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, 230088, China.<br /><searchLink fieldCode="AU" term="%22Nan+B%22">Nan B</searchLink>; Department of Otorhinolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Dong+D%22">Dong D</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Zen+Z%22">Zen Z</searchLink>; Department of ENT of the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.<br /><searchLink fieldCode="AU" term="%22Gao+Z%22">Gao Z</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Ye+C%22">Ye C</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200030, China. huang.xinsheng@zs-hospital.sh.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Otolaryngology, Yueyang Hospital of Integrative Chinese & Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China. eternityz@sina.com.<br /><searchLink fieldCode="AU" term="%22Li+GL%22">Li GL</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. genglin.li@fdeent.org.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China. genglin.li@fdeent.org.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China. genglin.li@fdeent.org.<br /><searchLink fieldCode="AU" term="%22Shu+Y%22">Shu Y</searchLink>; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; Institute of Biomedical Science, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China. yilai_shu@fudan.edu.cn.
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        Value: 10.1007/s00204-026-04410-2
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        Text: English
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      – TitleFull: Schizantherin B alleviates cisplatin-induced ototoxicity and does not interfere cisplatin-based chemotherapy in a breast cancer model.
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              M: 05
              Text: 2026 May 13
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              Y: 2026
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