Large-scale discovery, analysis and design of protein energy landscapes.

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Title: Large-scale discovery, analysis and design of protein energy landscapes.
Authors: Ferrari ÁJR; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Dixit SM; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Thibeault J; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Garcia M; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Houliston S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Ludwig RW; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Notin P; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Phoumyvong CM; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Martell CM; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Jung MD; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Tsuboyama K; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Institute of Industrial Science, The University of Tokyo, Tokyo, Japan., Carter L; Department of Biochemistry, University of Washington, Seattle, WA, USA., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Guttman M; Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA., Rocklin GJ; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. grocklin@gmail.com.; Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. grocklin@gmail.com.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. grocklin@gmail.com.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8120), pp. 1108-1118. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-026-10465-z