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Impaired glymphatic function and advanced brain age gap in chronic migraine: a multimodal MRI study.

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Title: Impaired glymphatic function and advanced brain age gap in chronic migraine: a multimodal MRI study.
Authors: Dai C; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Fu F; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Guo Y; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Liu X; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Tao Z; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Zhang X; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Li X; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Lin C; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Ye M; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Huang M; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China., Hu Y; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China., Liu K; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China., Cao Y; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Chen K; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Hu B; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China., Liu X; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. lxz_2088@hotmail.com.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China. lxz_2088@hotmail.com., Li Y; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. yanli@wzhealth.com.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China. yanli@wzhealth.com.
Source: The journal of headache and pain [J Headache Pain] 2026 May 13; Vol. 27 (1). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impaired glymphatic function and advanced brain age gap in chronic migraine: a multimodal MRI study.
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  Data: <searchLink fieldCode="AU" term="%22Dai+C%22">Dai C</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Fu+F%22">Fu F</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Tao+Z%22">Tao Z</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Lin+C%22">Lin C</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Ye+M%22">Ye M</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. lxz_2088@hotmail.com.; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang, 325027, China. lxz_2088@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. yanli@wzhealth.com.; Wenzhou Key Laboratory of Neurogenetics, Wenzhou, Zhejiang, 325027, China. yanli@wzhealth.com.
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  Data: <searchLink fieldCode="JN" term="%22100940562%22">The journal of headache and pain</searchLink> [J Headache Pain] 2026 May 13; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 May 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100940562 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1129-2377 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211292369%22">11292369 </searchLink><i>NLM ISO Abbreviation: </i>J Headache Pain <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s10194-026-02384-1
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